Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Approach For Optimized Dismantling Strategies And Design For Recycling Of Electric Traction Drives
Proceedings of the Conference on Production Systems and LogisticsWith the widespread adoption of electric vehicles (EVs), there arises a pressing need for sustainable processing of electric traction drives (ETDs) at the end of their life cycles.
Hahn, Roman +4 more
doaj +1 more source
Upscaling of Permanent Magnet Dismantling and Recycling through VALOMAG Project
Materials Proceedings, 2021 Neodymium-Iron-Boron (NdFeB) based permanent magnets are indispensable in today’s technology-driven society. Moreover, their use is likely to increase since they are key in clean energy applications such as wind turbines, hybrid/electric vehicles, and ...
Fernando Coelho +11 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Decommissioning of the ASTRA research reactor: Dismantling of the biological shield [PDF]
Nuclear Technology and Radiation Protection, 2006 The paper describes the dismantling of the inactive and activated areas of the biological shield of the ASTRA research reactor at the Austrian Research Center in Seibersdorf. The calculation of the parameters determining the activated areas at the shield
Meyer Franz, Steger Ferdinand
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
CONSIDERATIONS FOR THE DEVELOPMENT OF A DEVICE FOR THE DECOMMISSIONING OF THE HORIZONTAL FUEL CHANNELS IN THE CANDU 6 NUCLEAR REACTOR. PART 9 - CUTTING AND EXTRACTING DEVICE FUNCTIONING [PDF]
Fiabilitate şi Durabilitate, 2015 This paper presents a constructive solution proposed by the authors in order to achieve of a cutting and extracting device for the decommissioning of the horizontal fuel channels in the CANDU 6 nuclear reactor.
Constantin POPESCU +2 more
doaj
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
CONSIDERATIONS FOR THE DEVELOPMENT OF A DEVICE FOR THE DECOMMISSIONING OF THE HORIZONTAL FUEL CHANNELS IN THECANDU 6 NUCLEAR REACTOR. PART 8 - PRESENTATION OF THE CUTTING AND EXTRACTING DEVICE [PDF]
Fiabilitate şi Durabilitate, 2015 This paper present a constructive solution proposed by the authors in order to achieve of a cutting and extracting device for the decommissioning of the horizontal fuel channels in the CANDU 6 nuclear reactor.
Constantin POPESCU +2 more
doaj