Results 61 to 70 of about 463,913 (214)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Pregnancy in an SRY-Negative XX Developmental Sex Disorder Pig After Removing an Ovotestis

Veterinary Sciences
A 2-year-old Large White research gilt was presented to the Comparative Theriogenology service at WSU for infertility. She was produced from the transfer of genetically modified embryos obtained via in vitro fertilization (IVF) that had been treated with
Jewel Toenges, Ahmed Tibary, Jon Michael Oatley, Muhammad Salman Waqas, Colton Robbins, Michela Ciccarelli   +5 more
doaj   +1 more source

Disorder Of Sex Development : Ambiguous Genitalia, Partial Androgen Insensitivity Syndrome

Averrous: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2018
Disorders of sex development (DSDs) also known as “intersex” are congenital condition by mismatch in which chromosomal, gonadal and anatomical. One in 4.500 infants is born with abnormalities of External genitalia, and mostly unexplained in molecular ...
Rajuddin Rajuddin, Fauzan Fauzan
doaj   +1 more source

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs [PDF]

, 2019
In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the ...
Payan-Carreira, Rita
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The relevance of schizotypal traits for understanding interpersonal functioning in adolescents with psychiatric problems. [PDF]

, 2017
A
De Clercq, Barbara, Hutsebaut, Joost, van Aken, Marcel AG, Van der Heijden, Paul, Verbeke, Lize   +4 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

46,XY ovotesticular disorders of sex development: A therapeutic challenge

Pediatric Reports, 2017
46,XY ovotesticular disorder of sex development is extremely rare and indicates the presence of both testis and ovary in the same patient. Gender assignment in newborns represents a therapeutic challenge.
Maria-Grazia Scarpa, Massimo Di Grazia, Gianluca Tornese   +2 more
doaj   +1 more source

Aromatase Deficiency in Two Siblings with 46,XX Karyotype Raised as Different Genders: A Novel Mutation (p.R115X) in the CYP19A1 Gene

JCRPE, 2020
Aromatase deficiency rarely causes a 46,XX sexual differentiation disorder. The CYP19A1 gene encodes the aromatase enzyme which catalyses the conversion of androgens to oestrogens.
Samim Özen, Tahir Atik, Özlem Korkmaz, Hüseyin Onay, Damla Gökşen, Ferda Özkınay, Özgür Çoğulu, Şükran Darcan   +7 more
doaj   +1 more source

Young women with a disorder of sex development: learning to share information with health professionals, friends and intimate partners about bodily differences and infertility [PDF]

, 2015
Aim: To understand the experiences of young women with a disorder of sex development when sharing information about their body with healthcare professionals, friends and intimate partners.
Benner P., Biggerstaff D., Biordi D.L., Bowlby J., Collins N.L., Cromby J., Erickson E.H., Espie C., Kohlenberg R.J., Langdridge D., Maslow A.H., Slater J., Smith J.A.   +12 more
core   +1 more source