Results 41 to 50 of about 359,449 (281)

Whole-Exome Sequencing Identified Rare Genetic Variants Associated with Undervirilized Genitalia in Taiwanese Pediatric Patients

Biomedicines, 2023
Disorders/differences of sex development (DSDs) are a group of rare and phenotypically variable diseases. The underlying genetic causes of most cases of 46XY DSDs remains unknown.
Meng-Che Tsai, Yun-Han Weng, Yu-Fang Lin, Yi-Chieh Wang, Hui-Wen Yu, Yen-Yin Chou, Peng-Chieh Chen   +6 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

XY (SRY-positive) Ovarian Disorder of Sex Development in Cattle [PDF]

, 2018
In mammals, the sex of the embryo depends on the SRY gene. In the presence of at least one intact and functional copy of this genetic factor (XY embryo) undifferentiated gonads will develop as testicles that subsequently determine the male phenotype ...
F. Cremonesi, Lisa De Lorenzi, P. Grignani, C. Previderè, Pietro Parma, S. Arrighi, Elena Rossi, Carlo Previderè, L. De Lorenzi, Fausto Cremonesi, Stefania Bonacina, E. Rossi, Silvana Arrighi, S. Bonacina, P. Parma, Pierangela Grignani   +15 more
core   +2 more sources

Case report: Persistent Müllerian duct syndrome and enlarged prostatic utricle in a male dog

Frontiers in Veterinary Science, 2023
A 1-year-old male intact Miniature Schnauzer mix was presented for chronic intermittent hematuria. Abdominal ultrasonography revealed a large, fluid-filled cystic structure extending cranially and dorsally to the prostate. Computed tomography scan images
Peter J. Welsh, Kaylyn McDaniel, Elizabeth W. Goldsmith, Elizabeth W. Goldsmith, Joshua D. Ramsay, Alan Conley, Tina Jo Owen, Yoko M. Ambrosini, Michela Ciccarelli   +8 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Psychosocial correlates of recidivism in a sample of ex-prisoners: the role of Oppositional Defiant Disorder and Conduct Disorder

, 2014
The present study aimed to (a) examine the role of Oppositional Defiant Disorder and Conduct Disorder in predicting recidivism, while controlling for childhood arrest, perceived neighbourhood crime frequency, alcohol consumption, age, and gender, and (b)
Dhingra, Katie, Daniel Boduszek, Rachel Belsher, Katie Dhingra, Belsher, Rachel, Maria Ioannou, Boduszek, Daniel, Ioannou, Maria   +7 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Cortisol secretion in children with symptoms of reactive attachment disorder [PDF]

, 2013
Maltreated children with Reactive Attachment Disorder (RAD) have severe problems with social relationships and affect regulation. An association between early maltreatment and changes in the daily rhythm of cortisol secretion has already been reported ...
Kocovska, E., Follan, M., Gillberg, Christopher, Gillberg, C., Wallace, A.M., Puckering, C., Gorski, C., Follan, Michael, Young, D., Smillie, M., Minnis, H., Barnes, J., Gorski, Charlotta, Wallace, Alan Michael, Barnes, James, Wilson, P., Kocovska, Eva, Wilson, Philip, Minnis, Helen, Smillie, Maureen, Puckering, Christine, Young, David   +21 more
core   +1 more source

Clinical Case of the Complete Form of Androgen Insensitivity Syndrome (AIS)

Неотложная медицинская помощь, 2023
The article presents a clinical observation of an extremely rare in gynecological practice androgen insensitivity syndrome (AIS). The authors give data on the pathogenesis of the disease, modern classification and terminology of various forms of this ...
M. M. Damirov, I. V. Anchabadze, A. A. Medvedev, M. A. Eremenko   +3 more
doaj   +1 more source