Results 91 to 100 of about 129,709 (348)

Efficacy and safety of simultaneous rTMS–tDCS over bilateral angular gyrus on neuropsychiatric symptoms in patients with moderate Alzheimer's disease: A prospective, randomized, sham-controlled pilot study

Brain Stimulation, 2022
Background: Treating neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) remains highly challenging. Noninvasive brain stimulation using repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) is of ...
Yueqing Hu, Yu Jia, Ying Sun, Yan Ding, Zhaoyang Huang, Chunyan Liu, Yuping Wang   +6 more
doaj   +1 more source

Dynamic Changes of Brain Activity in Patients With Disorders of Consciousness During Recovery of Consciousness

Frontiers in Neuroscience, 2022
The disorder of brain activity dynamics is one of the main characteristics leading to disorders of consciousness (DOC). However, few studies have explored whether the dynamics of brain activity can be modulated, and whether the dynamics of brain activity
Yongkun Guo, Ruiqi Li, Rui Zhang, Chunying Liu, Lipeng Zhang, Dexiao Zhao, Qiao Shan, Xinjun Wang, Yuxia Hu   +8 more
semanticscholar   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group.

Clinical Neurophysiology, 2020
The analysis of spontaneous EEG activity and evoked potentialsis a cornerstone of the instrumental evaluation of patients with disorders of consciousness (DoC).
A. Comanducci, M. Boly, J. Claassen, M. Lucia, R. Gibson, E. Juan, Steven Laureys, L. Naccache, A. Owen, M. Rosanova, A. Rossetti, C. Schnakers, J. Sitt, N. Schiff, M. Massimini   +14 more
semanticscholar   +1 more source

Sleep patterns correlates with the efficacy of tDCS on post-stroke patients with prolonged disorders of consciousness

Journal of Translational Medicine, 2022
Background The subclassification of prolonged disorders of consciousness (DoC) based on sleep patterns is important for the evaluation and treatment of the disease.
Jie Yu, Yuehao Wu, Biwen Wu, Chuan Xu, Jiaye Cai, Xinrui Wen, Fanxia Meng, Li Zhang, Fangping He, Lirong Hong, Jian Gao, Jingqi Li, Jintai Yu, B. Luo   +13 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The limits of consciousness [PDF]

, 2018
Consciousness is essential for one’s normal functioning, including targeted interactions with the surrounding world and with other human beings. At present, many theories and definitions of consciousness coexist, the focus of which can be on the ...
Wolff, Audrey
core  

Multifaceted brain networks reconfiguration in disorders of consciousness uncovered by co-activation patterns

, 2017
peer reviewedIntroduction: Given that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network’s (DMN) connectivity in patients with disorders of ...
Larroque, Stephen K., Martial, Charlotte, Enrico Amico, Heine, Lizette, Stephen Karl Larroque, Amico, Enrico, Annen, Jitka, Andrea Soddu, Jitka Annen, Daniele Marinazzo, Soddu, Andrea, Laureys, Steven, Marinazzo, Daniele, Charlotte Martial, Amico, Enrico; id_orcid, Di Perri, Carol, Carol Di Perri, Larroque, Stephen Karl, Lizette Heine, Steven Laureys   +19 more
core   +1 more source

Pain in Persons with Disorders of Consciousness

Brain Science, 2022
Pain and suffering in persons with disorders of consciousness (DoC) remain poorly understood, frequently unaddressed or inadequately addressed, and controversial on numerous levels.
N. Zasler, R. Formisano, M. Aloisi
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source