Results 71 to 80 of about 129,709 (348)

Predicting outcome in disorders of consciousness: A mega‐analysis

Annals of Clinical and Translational Neurology
Assessing recovery potential in patients with disorders of consciousness (DoC) is pivotal for guiding clinical and ethical decisions. We conducted a mega‐analysis of individual patient data to understand (1) if a time threshold exists, beyond which ...
Y. G. Pavlov, Franziska Spiegelsberger, B. Kotchoubey   +2 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neuroscience of the Yogic Theory of Mind and Consciousness

, 2020
Yoga as a practice and philosophy of life has been followed for more than 4500 years with known evidence of Yogic practices in the Indus Valley Civilization. A plethora of scholars have contributed to the development of the field, but in last century the
Pallavi Bharadwaj, Bharadwaj, Pallavi, Vaibhav Tripathi, Tripathi, Vaibhav   +3 more
core   +1 more source

EEG hemispheric asymmetry and behavioral responsiveness following rTMS in unresponsive wakefulness syndrome: an exploratory study

Journal of NeuroEngineering and Rehabilitation
Background Hemispheric asymmetry is a fundamental feature of large-scale brain organization, yet its relevance to disorders of consciousness (DOC) and its modulation following repetitive transcranial magnetic stimulation (rTMS) remain insufficiently ...
Xiaochun Zheng, Qiuyi Xiao, Chengwei Xu, Zerong Chen, Zhanxing Yuan, Haili Zhong, Yang Bai, Xiyan Huang, Qiuyou Xie   +8 more
doaj   +1 more source

Detection of residual consciousness using EEG indicators related to rectal perception: protocol for a diagnostic accuracy study

Frontiers in Neurology
IntroductionAccurate diagnosis of disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), remains a long-standing and unresolved challenge in clinical practice.
Yilin Zhao, Yilin Zhao, Yitong Lian, Yitong Lian, Yinliang Qi, Steven Laureys, Steven Laureys, Steven Laureys, Steven Laureys, Haibo Di, Haibo Di, Weiqiao Zhao, Weiqiao Zhao   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ethical Considerations in Clinical Trials for Disorders of Consciousness

Brain Science, 2022
As the clinical trial landscape for patients with disorders of consciousness (DoC) expands, consideration of associated ethical challenges and opportunities is of ever-increasing importance. Responsible conduct of research in the vulnerable population of
Michael J. Young, Yelena G. Bodien, B. Edlow   +2 more
semanticscholar   +1 more source

The temporal dynamics of Large‐Scale brain network changes in disorders of consciousness: A Microstate‐Based study

CNS Neuroscience & Therapeutics, 2022
The resting‐state brain is composed of several discrete networks, which remain stable for 10–100 ms. These functional microstates are considered the building blocks of spontaneous consciousness.
Chunyun Zhang, Yi Yang, Shuai Han, Long Xu, Xueling Chen, Xiaoli Geng, L. Bie, Jianghong He   +7 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Disorders of Consciousness [PDF]

Mayo Clinic Proceedings, 2007
Preface: Nicholas D. Schiff and Steven Laureys. 1. Dualism persists in the science of mind: Athena Demertzi, Charlene Liew, Didier Ledoux, Marie-Aurelie Bruno, Steven Laureys, and Adam Zeman. 2. Synchrony in the Interconnected Circuitry of Thalamus and Cerebral Cortex: Edward G. Jones. 3.
Nicholas D. Schiff, Joseph J. Fins
openaire   +1 more source