Results 61 to 70 of about 166,123,844 (288)

Multifaceted brain networks reconfiguration in disorders of consciousness uncovered by co-activation patterns [PDF]

, 2017
peer reviewedIntroduction: Given that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network’s (DMN) connectivity in patients with disorders of ...
Larroque, Stephen K., Martial, Charlotte, Enrico Amico, Heine, Lizette, Stephen Karl Larroque, Amico, Enrico, Annen, Jitka, Andrea Soddu, Jitka Annen, Daniele Marinazzo, Soddu, Andrea, Laureys, Steven, Marinazzo, Daniele, Charlotte Martial, Amico, Enrico; id_orcid, Di Perri, Carol, Carol Di Perri, Larroque, Stephen Karl, Lizette Heine, Steven Laureys   +19 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Brain endogenous feedback and degrees of consciousness

, 2014
We present a model able to account for the mechanisms supporting different degrees of consciousness. We support our proposal with recent evidence from brain morphology and physiology, which indicate that the central nervous system contains two parallel ...
Carrara-Augustenborg, Claudia, Pereira, Alfredo [UNESP]   +1 more
core   +1 more source

Individualized music induces theta-gamma phase-amplitude coupling in patients with disorders of consciousness

Frontiers in Neuroscience
ObjectiveThis study aimed to determine whether patients with disorders of consciousness (DoC) could experience neural entrainment to individualized music, which explored the cross-modal influences of music on patients with DoC through phase-amplitude ...
Qiuyi Xiao, Qiuyi Xiao, Xiaochun Zheng, Xiaochun Zheng, Yun Wen, Zhanxing Yuan, Zerong Chen, Zerong Chen, Yue Lan, Shuiyan Li, Shuiyan Li, Xiyan Huang, Haili Zhong, Chengwei Xu, Chang’an Zhan, Jiahui Pan, Qiuyou Xie, Qiuyou Xie, Qiuyou Xie, Qiuyou Xie   +19 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Disorders of Consciousness [PDF]

Mayo Clinic Proceedings, 2007
Preface: Nicholas D. Schiff and Steven Laureys. 1. Dualism persists in the science of mind: Athena Demertzi, Charlene Liew, Didier Ledoux, Marie-Aurelie Bruno, Steven Laureys, and Adam Zeman. 2. Synchrony in the Interconnected Circuitry of Thalamus and Cerebral Cortex: Edward G. Jones. 3.
Nicholas D. Schiff, Joseph J. Fins
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source