Results 61 to 70 of about 294,184 (290)

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why are identity disorders interesting for philosophers? [PDF]

, 2003
"Identity disorders" constitute a large class of psychiatric disturbances that, due to deviant forms ofself-modeling, result in dramatic changes in the patients' phenomenal experience of their own personal identity.
Metzinger, Thomas
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The swallow, a target to follow the restauration of consciousness in acquired brain injury

Journal of Rehabilitation Medicine
Introduction: Brain injuries are the leading cause of disorders of consciousness and are often complicated by swallowing disorders. The aim of this study was to determine whether a correlation existed between swallowing and level of consciousness in ...
Anne Charlotte Lerick, Eleonore Sequeira, Jean Glenisson, Nikki Sabourin, Virgil Rolland, Gregoire Prum, Eric Verin   +6 more
doaj   +1 more source

Subcortical atrophy correlates with the perturbational complexity index in patients with disorders of consciousness

Brain Stimulation, 2020
Background: The complexity of neurophysiological brain responses to direct cortical stimulation, referred to as the perturbational complexity index (PCI), has been shown able to discriminate between consciousness and unconsciousness in patients surviving
Evan S. Lutkenhoff, Micah A. Johnson, Silvia Casarotto, Marcello Massimini, Martin M. Monti   +4 more
doaj   +1 more source

The Kantian Roots of Merleau-Ponty's Account of Pathology [PDF]

, 2014
One of the more striking aspects of Maurice Merleau-Ponty's Phenomenology of Perception (1945) is his use of psychological case studies in pathology.
Matherne, Samantha
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The ethical relevance of the unconscious

Philosophy, Ethics, and Humanities in Medicine, 2017
Background Ethical analyses of disorders of consciousness traditionally focus on residual awareness. Going one step further, this paper explores the potential ethical relevance of the unawareness retained by patients with disorders of consciousness ...
Michele Farisco, Kathinka Evers
doaj   +1 more source

Institutional paraconsciousness and its pathologies [PDF]

, 2006
This analysis extends a recent mathematical treatment of the Baars consciousness model to analogous, but far more complicated, phenomena of institutional cognition.
Wallace, Rodrick
core