Results 231 to 240 of about 990,174 (349)

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

A novel variant in the <i>MAP3K1</i> genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development. [PDF]

Mol Med Rep
Lu Y, Wei S, Wang S, Zhang J, Xu Y, Huang C, Pan W, Wang Z.   +7 more
europepmc   +1 more source

The role of ultrasound to evaluate the disorders of sex development: a pictorial essay. [PDF]

J Ultrasound, 2022
Hosokawa T, Tanami Y, Sato Y, Hosokawa M, Oguma E.   +4 more
europepmc   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Profile of <i>DHX37</i> gene defects in human genetic diseases: 46,XY disorders of sex development. [PDF]

Front Endocrinol (Lausanne)
Peng H, Peng W, Chen J, Hu K, Zhang Y, Ma Y, Jiang H.   +6 more
europepmc   +1 more source

Translational Genetics for Diagnosis of Human Disorders of Sex Development

, 2013
Ruth M. Baxter, Éric Vilain
openalex   +1 more source

Effects of chromosomal sex and hormonal influences on shaping sex differences in brain and behavior: Lessons from cases of disorders of sex development [PDF]

, 2016
Matthew S. Bramble, Allen Lipson, Neerja Vashist, Éric Vilain   +3 more
openalex   +1 more source

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients

Advanced Science, EarlyView.
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang, Xiangqin Ou, Jingyi Lin, Xiaofei Luo, Jiashun Zhou, Xingyue Zhou, Peihua Zhao, Li Liu, Ziran Zhao, Ying Zhou, Guanwei Fan, Lifeng Han, Xiumei Gao   +12 more
wiley   +1 more source

Clinical tools in the diagnosis of disorders of sex development: a switch from the hormonal to the genetics laboratory? [PDF]

Adv Lab Med, 2021
Rey RA.
europepmc   +1 more source

Mutation analysis of mitogen activated protein kinase 1 gene in Indian cases of 46,XY disorder of sex development

, 2013
Dhanjit Kumar Das, SubodhG Rahate, BhaktiP Mehta, Harshavardhan Gawde, Parag Tamhankar   +4 more
openalex   +2 more sources