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Current Opinion in Obstetrics & Gynecology, 2007
The current management of patients with intersex, now designated as disorders of sex development, is presented in the context of updated etiological and outcome data, refined surgical procedures and the need for a multidisciplinary approach.The recently published consensus statement, the primary publication cited herein, includes known genetic causes ...
Zeina M, Nabhan, Peter A, Lee
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The current management of patients with intersex, now designated as disorders of sex development, is presented in the context of updated etiological and outcome data, refined surgical procedures and the need for a multidisciplinary approach.The recently published consensus statement, the primary publication cited herein, includes known genetic causes ...
Zeina M, Nabhan, Peter A, Lee
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2020
Disorders of sex development (DSDs) are characterized by discordance between phenotypic, gonadal, and genetic sex. DSDs can be classified into three categories based on karyotype: 46,XX, 46,XY, and sex chromosome DSDs. While many of the underlying genetic etiologies of DSDs are known, many remain elusive.
Prasad Godbole, Neil Wright
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Disorders of sex development (DSDs) are characterized by discordance between phenotypic, gonadal, and genetic sex. DSDs can be classified into three categories based on karyotype: 46,XX, 46,XY, and sex chromosome DSDs. While many of the underlying genetic etiologies of DSDs are known, many remain elusive.
Prasad Godbole, Neil Wright
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Pediatric disorders of sex development
The Indian Journal of Pediatrics, 2009The management of disorders of sexual differentiation (DSD) involves a multidisciplinary approach. The main aim of analysis was to study the phenotype-karyotype correlation in North Indian children with DSD. The records of pediatric DSD were retrieved and characteristics noted. Of total of 58 children, 43 (74.1%) and 10 (17.2%) were raised as males and
Ketan Prasad, Kulkarni +4 more
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Surgery (Oxford), 2016
A 20-year-old individual presented with poor development of secondary sexual characteristics and primary amenorrhea. She was born of a non-consanguineous marriage at term by vaginal delivery at home without any perinatal complications and was assigned female gender.
Anil Bhansali +3 more
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A 20-year-old individual presented with poor development of secondary sexual characteristics and primary amenorrhea. She was born of a non-consanguineous marriage at term by vaginal delivery at home without any perinatal complications and was assigned female gender.
Anil Bhansali +3 more
+4 more sources
Update on disorders of sex development
Current Opinion in Endocrinology, Diabetes & Obesity, 2012To review the recent information regarding disorders of sex development (DSD) which contribute to, as well as highlight, the need for greater understanding of genetic mutations and the dire need for specific outcome information.New information is primarily related to the identification of genetic mutations and other gene variations that impact ...
Christopher P, Houk, Peter A, Lee
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Tumor Risk in Disorders of Sex Development
Sexual Development, 2010Certain patients with disorders of sex development (DSD), who bear Y chromosome material in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT), which arise from early fetal germ cells. DSD gonads frequently harbor immature germ cells which express early fetal germ cell markers. Some of them (e.g.
Pleskacova, J +9 more
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Sex Hormone Replacement in Disorders of Sex Development
2014People with disorders of sex development (DSD) may have impaired sex steroid production or their gonads removed before, during or after adolescence, thus requiring hormone replacement therapy (HRT) to induce puberty and/or maintain secondary sexual characteristics, to optimize bone health, and to promote physical and social well-being.
Wiebke, Birnbaum, Silvano, Bertelloni
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Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex Development
2012It can be argued that the sex chromosomes are the most important pair of chromosomes given their role in determining gender and, therefore, allowing for reproduction and procreation. Considered together, sex chromosome aneuploidies are the most common chromosome abnormalities seen in live-born infants, children, and adults.
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Pediatric Care Online
Key Points Disorders of sex development (DSD) are congenital conditions in which development of chromosomal, gonadal, or anatomical (genital) sex is not typical for that expected for a male or female.Most DSDs are caused by genetic mutations in hormone metabolism or action, or in gonadal development.The evaluation for a suspected DSD ...
Juline A. Asamoah, Ryan A. Clagg
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Key Points Disorders of sex development (DSD) are congenital conditions in which development of chromosomal, gonadal, or anatomical (genital) sex is not typical for that expected for a male or female.Most DSDs are caused by genetic mutations in hormone metabolism or action, or in gonadal development.The evaluation for a suspected DSD ...
Juline A. Asamoah, Ryan A. Clagg
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2010
The contribution of imaging in disorders of sex development is not confined to the diagnosis of the underlying condition. Imaging has an important role in assisting pre-operative planning where surgery is contemplated, in identifying the location of occult gonads and in assessment of suspected complications of these conditions, including malignant ...
Justin H. Davies +2 more
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The contribution of imaging in disorders of sex development is not confined to the diagnosis of the underlying condition. Imaging has an important role in assisting pre-operative planning where surgery is contemplated, in identifying the location of occult gonads and in assessment of suspected complications of these conditions, including malignant ...
Justin H. Davies +2 more
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