Results 71 to 80 of about 169,190,458 (279)

Autistic traits and autism spectrum disorders : the clinical validity of two measures presuming a continuum of social communication skills [PDF]

, 2010
Research indicates that autism is the extreme end of a continuously distributed trait. The Social Responsiveness Scale (SRS) and the Social and Communication Disorders Checklist (SCDC) aim to assess autistic traits.
Westerwald, Eva, Westerwald, E., Westerwald, E, Holtmann, M, Holtmann, M., Bölte, Sven, Freitag, C, Christine Freitag, Bolte, S, Holtmann, Martin, Eva Westerwald, Sven Bölte, Freitag, C., Fritz Poustka, Freitag, Christine M., Martin Holtmann, Poustka, F., Poustka, F, Poustka, Fritz   +18 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Development Effectiveness Overview (DEO) 2020

, 2020
The Development Effectiveness Overview (DEO) is an annual report produced by the IDB Group to share the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
core   +1 more source

Clinico-epidemiological profile of disorders of sex development at a tertiary referral hospital in South Kalimantan, Indonesia

Universa Medicina
Background Disorders of sex development (DSD) comprise a group of complex conditions that pose significant diagnostic and clinical issues. This study aimed to describe the clinical spectrum, temporal patterns, and geographical distribution of DSD cases ...
Maria Ulfah, Indra Widjaya Himawan, Niarsari Anugrahing Putri, Naisya Balela, Aulia Mufida, Nashwa Rifda Agustina, Nur Aisyah Munawaroh Ayu   +6 more
doaj   +1 more source

THE RISK FOR DEVELOPING TUMOR IN PATIENTS WITH GONADAL DYSGENESIS 46,XY

Бюллетень сибирской медицины, 2015
Disorders of sex development with Y chromosome material has been associated with a high risk for developing germ cell tumors such as gonadoblastoma or dysgerminoma.
O. Yu. Latyshev, L. N. Samsonova, E. P. Kasatkina, G. F. Okminyan, Ye. V. Kiselyova, Ye. S. Timofeyeva   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Unveiling the Significance of the Androgen Receptor Gene in Disorders of Sex Development

Advances in Human Biology
Disorders of sex development (DSD) encompass a range of congenital conditions where the development of chromosomal, gonadal or anatomical sex is atypical. There are many genes associated with DSD, and one of them is the androgen receptor (AR) gene, which
Ziske Maritska, M Irsan Saleh, Fachmi Idris, Zen Hafy, Didit Pramudhito, Kemas Yusuf Effendi   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

46,XY ovotesticular disorders of sex development: A therapeutic challenge

Pediatric Reports, 2017
46,XY ovotesticular disorder of sex development is extremely rare and indicates the presence of both testis and ovary in the same patient. Gender assignment in newborns represents a therapeutic challenge.
Maria-Grazia Scarpa, Massimo Di Grazia, Gianluca Tornese   +2 more
doaj   +1 more source