Results 51 to 60 of about 2,838 (167)

A Phase 1, Open‐Label, Randomized Study to Investigate the Pharmacokinetics and Safety of Multiple Doses of Intranasal Naloxone in Healthy Participants

open access: yesClinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT This was a Phase 1, open label, randomized, crossover study to evaluate the safety and pharmacokinetics of multiple doses of intranasal naloxone (NCT05377255). Twenty‐four healthy participants were enrolled at a single site in the US to one of two sequences.
David Cassie   +4 more
wiley   +1 more source

Ovarian malignancy in an individual with 46,XY ovotesticular disorder of sexual development – A case report

open access: yesUrology Case Reports
Disorders of sexual development (DSD) are diseases resulting from aberrations in sex chromosomes, gonadal, and internal/external genitalia development resulting in various phenotypes.
James I. Griggers   +2 more
doaj   +1 more source

Ovotesticular disorder of sex development in a 46 XY adolescent: a rare case report with review of the literature

open access: yesBMC Women's Health, 2023
Introduction : Ovotestis is a rare cause of sexual ambiguity characterized by the presence in a patient of both testicular and ovarian tissue, leading to the development of both male and female structures.
Koui Bbs   +6 more
doaj   +1 more source

Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION This study aimed to investigate whether sleep quality predicts cognitive/functional decline, and whether Alzheimer's disease (AD) pathology modifies these relationships. METHODS The Pittsburgh Sleep Quality Index was administered to 326 older adults (113 cognitively normal, 192 mild cognitive impairment, 21 dementia; mean age = 66.
Layaly Shihadeh   +15 more
wiley   +1 more source

Genetics of Disorders of Sex Development: The DSD-TRN Experience.

open access: yesEndocrinology and metabolism clinics of North America, 2018
Although many next-generation sequencing platforms are being created around the world, implementation is facing multiple hurdles. A strong hurdle to the full adherence of clinical teams to the Disorders of Sex Development Translational Research Network (DSD-TRN) guidelines for standardization of reporting and practice is the current lack of integration
Délot, Emmanuèle   +3 more
openaire   +3 more sources

Ultrasonography for disorders of sex development in pediatrics

open access: yesFrontiers in Pediatrics
ObjectiveThis study aimed to evaluate the clinical value of ultrasonography in the management of disorders of sex development (DSDs).MethodsUltrasonographic appearance and clinical data of 82 cases with DSD were reviewed retrospectively.ResultsIn total ...
Yuting Wu   +3 more
doaj   +1 more source

Features of sexual development in newborns: variants of the norm and deviation

open access: yesСучасна педіатрія: Україна
The identification of the person's biological sex based on various anatomical, physiological, and genetic markers that distinguish men from women, includes genetic, gonadal, and phenotypic sex types.
V.M. Dudnyk   +4 more
doaj   +1 more source

Should We Consider Sacral Nerve Stimulation as a Treatment for Neurogenic Lower Urinary Tract Dysfunction? ICI‐RS 2025

open access: yesNeurourology and Urodynamics, Volume 45, Issue 5, Page 945-950, June 2026.
ABSTRACT Aims To explore the boundary of clinical use of sacral nerve stimulation (SNS) in neurogenic lower urinary tract dysfunction (NLUTD), identifying barriers to approval and early‐impact research questions. Methods This review is derived from a proposal discussion at the International Consultation on Incontinence‐Research Society in Bristol in ...
Marcus J. Drake   +6 more
wiley   +1 more source

Which Patients With Dysfunctional Voiding Respond Well to Sacral Neuromodulation? ICI‐RS 2025

open access: yesNeurourology and Urodynamics, Volume 45, Issue 5, Page 937-944, June 2026.
ABSTRACT Aims Dysfunctional voiding (DV) is characterised by fluctuating or intermittent urinary flow during voiding in neurologically normal individuals. Given the different definitions used and heterogeneous pathophysiologies, outcomes following sacral neuromodulation/sacral nerve stimulation (SNM/SNS) are variably reported.
Jalesh N. Panicker   +8 more
wiley   +1 more source

Améliorer les pratiques de soins pour les personnes présentant une variation du développement du sexe en Suisse. L’École de Lausanne (depuis 2005)

open access: yesDroit et Cultures, 2021
This article presents a short history of the Lausanne School or “Swiss model” (as it is sometimes called abroad) created in the context of an interdisciplinary “SHS and gender in medicine” project we launched in 2005 to improve medical care for persons ...
Cynthia Kraus   +3 more
doaj  

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