Results 231 to 240 of about 93,533 (290)

Real-Life Use of Subcutaneous Biologicals and JAK Inhibitors in IBD Maintenance Therapy: Treatment Continuation, Switching Patterns, and Concomitant Medications. [PDF]

Clin Exp Gastroenterol
Koivusalo M, Jokelainen J, Huhtinen A, Kovac B, Silvola S, Torvinen S, Ylisaukko-Oja T, Arkkila P.   +7 more
europepmc   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Trends in Antithrombotic Therapy Initiation Among Patients With Stroke Pre- and Post-COVID-19 in Sweden-An Interrupted Time Series Study. [PDF]

Basic Clin Pharmacol Toxicol
Mousa S, Persson K, Palmetun-Ekbäck M, Nyberg F, Li H, Wettermark B, Hajiebrahimi M.   +6 more
europepmc   +1 more source

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era.

JAMA Netw Open
Socias ME, Lei J, Zhou V, Anand R, Cui Z, Penta S, Larochelle M, Lodi S, Fairbairn N.   +8 more
europepmc   +1 more source

A Description of QT-Interval Prolonging Drug Interactions with Fluoroquinolones in Older Women with Uncomplicated Urinary Tract Infections. [PDF]

Can Geriatr J
Trenaman SC, von Maltzahn M, Stewart SA, Tamim H, Sketris I, Black E.   +5 more
europepmc   +1 more source

Design and Optimization of Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces Based on Conditional Multi‐Task Deep Learning

Advanced Science, EarlyView.
A conditional multi‐task deep learning framework is developed for designing and optimizing Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces (FHPEMs). This framework achieves joint spectro‐polarimetric learning and unified forward–inverse design.
Chenjie Gong, Haodong Shi, Qi Wang, Yingchao Li, Hongyu Sun, Jiayu Wang, Guanlin Li, Jian Zhang, Qiang Fu, Huilin Jiang   +9 more
wiley   +1 more source

Discontinuation and reinitiation of pharmacological treatment for ADHD among individuals with ADHD and substance use disorder. [PDF]

BMJ Ment Health
Capusan AJ, Zhang L, Larsson H, Brikell I, Martinez D, D'Onofrio BM, Lichtenstein P, Kuja-Halkola R, Chang Z.   +8 more
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Development of a standard operating procedure for investigational product rights of administration in clinical trials. [PDF]

J Clin Transl Sci
Hill L, Jones CT.
europepmc   +1 more source