Results 61 to 70 of about 556,522 (351)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Factorial Dispersion Models

International Statistical Review / Revue Internationale de Statistique, 1987
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Speed, T. P., Bailey, R. A.
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Beyond inappropriate fire regimes: A synthesis of fire‐driven declines of threatened mammals in Australia

Conservation Letters, 2022
Fire can promote biodiversity, but changing patterns of fire threaten species worldwide. While scientific literature often describes ‘‘inappropriate fire regimes’’ as a significant threat to biodiversity, less attention has been paid to the ...
Julianna L. Santos, Bronwyn A. Hradsky, David A. Keith, Kevin C. Rowe, Katharine L. Senior, Holly Sitters, Luke T. Kelly   +6 more
doaj   +1 more source

A new dispersal area of roe deer(Capreolus capreolus L. 1758): Karagüney Mountains, Kırıkkale

Turkish Journal of Forestry, 2021
Roe deer (Capreolus capreolus L. 1758) is spread all over Europe, including in the west of Russia, and in the Anatolian and Caucasian regions. Roe deer is found in the Marmara, Black Sea regions, Hakkari, Izmir, and Amanos Region.
Ali Uğur Özcan
doaj   +1 more source

Is a nonlocal diffusion strategy convenient for biological populations in competition? [PDF]

, 2015
We study the convenience of a nonlocal dispersal strategy in a reaction-diffusion system with a fractional Laplacian operator. We show that there are circumstances - namely, a precise condition on the distribution of the resource - under which a nonlocal
Massaccesi, Annalisa, Valdinoci, Enrico
core   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Distance-2-Dispersion: Dispersion with Further Constraints

, 2023
The aim of the dispersion problem is to place a set of $k(\leq n)$ mobile robots in the nodes of an unknown graph consisting of $n$ nodes such that in the final configuration each node contains at most one robot, starting from any arbitrary initial configuration of the robots on the graph.
Kaur, Tanvir, Mondal, Kaushik
openaire   +2 more sources