Results 101 to 110 of about 2,741,856 (378)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs

Pharmaceutics, 2018
Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang, Huijie Xing, Yue Zhao, Zhiguo Ma   +3 more
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Dispersion-managed soliton in a strong dispersion map limit

, 2001
A dispersion-managed optical system with step-wise periodical variation of dispersion is studied in a strong dispersion map limit in the framework of path-averaged Gabitov-Turitsyn equation. The soliton solution is obtained by iterating the path-averaged
Ablowitz, Gabitov, Kumar, Lakoba, Lin, Lushnikov, Lushnikov, Mollenauer, Nakazawa, P. M. Lushnikov, Pelinovsky, Smith, Turitsyn, Zharnitsky, Zharnitsky   +14 more
core   +1 more source

The effect of horizontal pay dispersion on the effectiveness of performance-based incentives [PDF]

, 2020
In response to general calls for increased transparency in society, pay transparency policies are growing in importance. Given that pay transparency unavoidably gives employees the opportunity to make comparisons between themselves and others, in this ...
Grabner, Isabella, Martin, Melissa A.
core  

Controlling the sign of chromatic dispersion in diffractive optics [PDF]

, 2017
Diffraction gratings disperse light in a rainbow of colors with the opposite order than refractive prisms, a phenomenon known as negative dispersion [1, 2].
E. Arbabi, A. Arbabi, Seyedeh Mahsa Kamali, Y. Horie, A. Faraon   +4 more
semanticscholar   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

In-situ Preparation of Hydroxyapatite-Carbon Nanotubes Nanocomposite and Investigation of its Microstructure and Morphology

Journal of Advanced Materials in Engineering, 2011
In the present study, in-situ synthesis of carbon nanotube/hydroxyapatite nano composite powder with stable homogeneous dispersions of carbon nanotubes (CNTs) was carried out using surfactant as dispersing agent. By applying sol-gel method, dispersion in
J. Jaafaripour Maybody, E. Salahi, A. Nemati, M.H. Amin   +3 more
doaj  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Fast and broadband fiber dispersion measurement with dense wavelength sampling

, 2014
We report on a method to obtain dispersion measurements from spectral-domain low-coherence interferograms which enables high accuracy (~ps/(nm·km)), broadband measurements and the determination of very dense (up to 20 points/nm over 500 nm) data sets for
Feng, Xian, Horak, Peter, Petropoulos, Periklis, Petrovich, Marco N., Poletti, Francesco, Ponzo, Giorgio M., Richardson, David J.   +6 more
core   +1 more source