Results 161 to 170 of about 2,741,856 (378)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
REACCIÓN Y DIFUSIÓN: DOS FACTORES CLAVES EN LA TÉCNICA DE COMBUSTIÓN IN SITU
Revista Fuentes El Reventón Energético, 2012 Currently, around the world, 64% of the reserves are composed of heavy oil, which is not easily extracted by conventional methods. In order to exploit these deposits, some techniques have been developed for enhanced oil recovery, all of them with ...
Andrés Jair Yatte Garzón +2 more
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Optimization of the process of calcium-carbonate dispersion stabilization for paper industry needs [PDF]
Tehnika, 2018 This paper presents the optimized technological process for obtaining stable calcium carbonate dispersion (CaCO3) in accordance to the standard prescribed in the paper industry.
Marinković Aleksandar D. +4 more
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XXII. Anomalous magnetic rotatory dispersion of neodymium [PDF]
, 1908 R.W. Wood
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
The Effect of Dispersion on the Interference Figures of Crystals [PDF]
, 1924 C. V. Raman
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
LX. On the refraction and dispersion of gaseous compounds, and the cause of the divergence from additive relations [PDF]
, 1913 Clive Cuthbertson
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