Results 151 to 160 of about 471,474 (315)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A new results in the analysis of the multidimensional data: multidimensional-matrix polynomial regression analysis

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The new results in the analysis of the multidimensional data received in the BSUIR in the area of the polynomial regression analysis are discussed. The statement of the problem of the regression analysis under conditions of the multidimensional-matrix ...
V. S. Mukha
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characteristics of clay dispersion and its influencing factors in saline-sodic soils of Songnen Plain, China

Agricultural Water Management
Under the influence of salinity-sodicity stress, soil salinization and sodification tend to be severe and the dispersion of clay particles increases, which threatens agricultural production and food security.
X.J. Luo, X. Zhang, L. Zhang, L.L. Guo, Z.Y. Nie, J. Zhou, R.Z. Wang, T.Y. Zhang, Y. Miao, L. Ma, Z.C. Wang, F. Yang   +11 more
doaj   +1 more source

Single Versus Multi-channel Dispersion Analysis of Ultrasonic Guided Waves Propagating in Long Bones. [PDF]

Ultrason Imaging, 2021
Tran TNHT, He F, Zhang Z, Sacchi MD, Ta D, Le LH.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Wave Dispersion Analysis of Fluid Conveying Nanocomposite Shell Reinforced by MWCNTs Considering the Effect of Waviness and Agglomeration Efficiency. [PDF]

Polymers (Basel), 2021
Alkhedher M, Talebizadehsardari P, Eyvazian A, Khan A, Farouk N.   +4 more
europepmc   +1 more source

Relative dispersion analysis [PDF]

Acta Ophthalmologica Scandinavica, 1999
IESTER, MICHELE, ALTIERI M, TRAVERSO, CARLO, CAPRIS, PAOLO, ZINGIRIAN M.   +4 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Robust estimation of mean and dispersion functions in extended generalized additive models. [PDF]

Generalized Linear Models are a widely used method to obtain parametric estimates for the mean function. They have been further extended to allow the relationship between the mean function and the covariates to be more flexible via Generalized Additive ...
Croux, Christophe, Prosdocimi, Ilaria, Gijbels, Irène   +2 more
core   +2 more sources