Results 81 to 90 of about 1,346,635 (301)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
ProceedingsThis study evaluates the bonding condition of concrete slabs with varying porosity levels (20% to 80%) at cold joint interfaces by analyzing surface wave dispersion velocity profiles.
Hong-Yao Cai +2 more
doaj +1 more source
Dispersion curve calculation in viscoelastic tissue-mimicking materials using non-parametric, parametric, and high-resolution methods. [PDF]
Ultrasonics, 2021 Kijanka P, Urban MW.
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Dipole Flexural Wave Dispersion Correction Method Based on Fully Connected Deep Neural Network
Cejing jishuIn dipole acoustic logging, the dispersion of flexural waves complicates shear wave velocity extraction. Traditional dispersion correction algorithms rely on repeated forward modeling of the dispersion equation, which is extremely time-consuming.
Peng Shuo +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Application of SPAC method in dividing strata of the Quaternary strata
河南理工大学学报. 自然科学版The SPAC method is one of the most effective methods of extracting phase velocity from environmental noise. The calculation of S-wave velocity structure by the SPAC method has important scientific significance for studying velocity structure.ObjectivesTo
LI Baochun, SUN Shaohuai, LI Guoping
doaj +1 more source
Barely visible impact damage identification in a 3D core sandwich structure
Computer Assisted Methods in Engineering and Science, 2018 3D core sandwich structure (3DCSS) is a popular lightweight construction material in the automotive, aerospace and marine industries. However, barely visible low-speed impact-damage (BVLID) may occur in the 3DCSS due to foreign-object-impact that can ...
Shirsendu Sikdar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source