Results 81 to 90 of about 607,204 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Kerr non-linearity in a superconducting Josephson metamaterial

, 2018
We present a detailed experimental and theoretical analysis of the dispersion and non-linear Kerr frequency shifts of plasma modes in a one-dimensional Josephson junction chain containing 500 SQUIDs in the regime of weak nonlinearity.
Basko, D., Buisson, Olivier, Dassonneville, R., Dumur, E., Guichard, Wiebke, Hekking, J., Krupko, Yu., Naud, C., Nguyen, V., Puertas, J., Roch, N., Weißl, T.   +11 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Spin dynamics simulations of the magnetic dynamics of RbMnF$_3$ and direct comparison with experiment

, 1999
Spin-dynamics techniques have been used to perform large-scale simulations of the dynamic behavior of the classical Heisenberg antiferromagnet in simple cubic lattices with linear sizes $L\leq 60$. This system is widely recognized as an appropriate model
A. Bunker, A. Cuccoli, A. Tucciarone, Alex Bunker, B.I. Halperin, B.I. Halperin, B.I. Halperin, C.G. Windsor, D. P. Landau, D.C. Rapaport, D.T. Teaney, D.T. Teaney, F. Keffer, G.F. Mazenko, J. Frank, K. Chen, K. Chen, M. F. Collins, M. Krech, M.E. Fisher, M.J. Freiser, P.C. Hohenberg, R. Coldea, R. Freedman, R. Freedman, R.W. Gerling, S. W. Lovesey, S.J. Pickart, Shan-Ho Tsai, U.J. Cox   +29 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Unit Cell Optimization of Groove Gap Waveguide for High Bandwidth Microwave Applications

Applied Sciences
Recently, groove gap waveguides (GGWs) have shown significant potential in power handling and bandwidth enhancement compared to conventional waveguides.
Ghiayas Tahir, Arshad Hassan, Shawkat Ali, Amine Bermak   +3 more
doaj   +1 more source

Studies of one- and two-hole states in the 2D t-J model via series expansions

, 1998
We study one and two hole properties of the t-J model at half-filling on the square lattice using series expansion methods at T=0. The dispersion curve for one hole excitations is calculated and found to be qualitatively similar to that obtained by other
Hamer, C. J., Oitmaa, J., Weihong, Zheng
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Microscopic theory of the coupling of intrinsic Josephson oscillations and phonons

, 2000
A microscopic theory for the coupling of intrinsic Josephson oscillations and dispersive phonon branches in layered superconductors is developed. Thereby the effect of phonons on the electronic c-axis transport enters through an effective longitudinal ...
Ch. Helm, Ch. Preis, Ch. Walter, Helm, Helm, J. Keller, K. Schmalzl, Kleiner, Kleiner, Kulkarni, Schlenga, Schlenga, Seidel, Tajima, Yurgens   +14 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source