Results 91 to 100 of about 807,113 (273)

Two-Source Dispersers for Polylogarithmic Entropy and Improved Ramsey Graphs [PDF]

open access: yesSIAM Journal on Computing, 2016
In his 1947 paper that inaugurated the probabilistic method, Erdös proved the existence of $(2+o(1))\log{n}$-Ramsey graphs on $n$ vertices. Matching Erdös's result with a constructive proof is considered a central problem in combinatorics and has gained significant attention in the literature.
openaire   +5 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Developing a novel hybrid method based on dispersion entropy and adaptive boosting algorithm for human activity recognition

open access: yes, 2023
Developing a novel hybrid method based on dispersion entropy and adaptive boosting algorithm for human activity ...
S Abdulla (38962)   +4 more
core  

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Cumulative Paired φ-Entropy

open access: yesEntropy, 2016
A new kind of entropy will be introduced which generalizes both the differential entropy and the cumulative (residual) entropy. The generalization is twofold.
Ingo Klein   +2 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Dispersion Entropy-based Fuzzy Classification for Motor Imagery Electroencephalogram

open access: yes, 2022
Fuzzy logic-based systems are a widely used method for both classification and control. Electroencephalography sign is frequently used in some studies such as Brain-Computer Interfaces.
Balcı, Furkan
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A Novel Weak Feature Extraction Method for Rotating Machinery: Link Dispersion Entropy

open access: yes, 2023
The entropy-based feature extraction is a promising tool for extracting weak features from rotating machinery. However, the existing research has paid little attention to the state transition process, which brings the problem of accuracy and ...
Shun Wang   +11 more
core   +1 more source

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