Results 71 to 80 of about 23,082 (239)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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Dispersal (Entropy) and Recognition (Information) as Foundations of Emergence and Dissolvence [PDF]
Entropy, 2009 The objective of this essay is to reflect on a possible relation between entropy and emergence. A qualitative, relational approach is followed. We begin by highlighting that entropy includes the concept of dispersal, relevant to our enquiry. Emergence in complex systems arises from the coordinated behavior of their parts.
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Physiological ReportsHuman sensory, cognitive, and motor processes often result in asymmetric cerebral hemisphere activation, observable through neurovascular coupling (NVC).
Héctor Rojas‐Pescio +3 more
doaj +1 more source
Two-Source Dispersers for Polylogarithmic Entropy and Improved Ramsey Graphs [PDF]
SIAM Journal on Computing, 2016 In his 1947 paper that inaugurated the probabilistic method, Erdős proved the existence of $2\log{n}$-Ramsey graphs on $n$ vertices. Matching Erdős' result with a constructive proof is a central problem in combinatorics, that has gained a significant attention in the literature. The state of the art result was obtained in the celebrated paper by Barak,
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Dispersion entropy: A Measure of Irregularity for Graph Signals
, 2023 We introduce a novel method, called Dispersion Entropy for Graph Signals, $DE_G$, as a powerful tool for analysing the irregularity of signals defined on graphs. We demonstrate the effectiveness of $DE_G$ in detecting changes in the dynamics of signals defined on synthetic and real-world graphs, by defining mixed processing on random geometric graphs ...
Fabila-Carrasco, John Stewart +2 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Entropy, 2016 A new kind of entropy will be introduced which generalizes both the differential entropy and the cumulative (residual) entropy. The generalization is twofold.
Ingo Klein +2 more
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