The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Solution of the Burger’s Equation for Longitudinal Dispersion Phenomena Occurring in Miscible Phase Flow through Porous Media [PDF]
An approximate solution of longitudinal dispersion phenomena occurring in two phase miscible fluid flow through porous media has been obtained by using the group theoretic approach.
Monika N. Mehta +2 more
doaj +1 more source
Tracer Dispersion in Rough Open Cracks [PDF]
Tracer dispersion is studied in an open crack where the two rough crack faces have been translated with respect to each other. The different dispersion regimes encountered in rough-wall Hele-Shaw cell are first introduced, and the geometric dispersion ...
Plouraboué, Franck +2 more
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Transverse and Longitudinal Thermomagnetic Waves in Conducting Media
The excited thermomagnetic wave in anisotropic conducting media is analyzed theoretically at different directions of the gradient of the temperature ÑT , relative to the wave vector k .
E.R. Hasanov +2 more
doaj +1 more source
Modelling solute transport in soil columns using advective-dispersive equations with fractional spatial derivatives [PDF]
Solute transport in soils is commonly simulated with the advective–dispersive equation, or ADE. It has been reported that this model cannot take into account several important features of solute movement through soil.
San Jose Martinez, Fernando
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Turbulent dispersion in cloud-topped boundary layers [PDF]
Compared to dry boundary layers, dispersion in cloud-topped boundary layers has received less attention. In this LES based numerical study we investigate the dispersion of a passive tracer in the form of Lagrangian particles for four kinds of atmospheric
Vilà-Guerau de Arellano, J. (author) +11 more
core +3 more sources
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source

