Results 101 to 110 of about 848,098 (285)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
An analytical model for the dispersion measure of Fast Radio Burst host galaxies
The Open Journal of AstrophysicsThe dispersion measure (DM) of fast radio bursts (FRBs) is sensitive to the electron distribution in the Universe, making it a promising probe of cosmology and astrophysical processes such as baryonic feedback.
Robert Reischke +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Astrophysical JournalThe Macquart relation describes the correlation between the dispersion measure (DM) of fast radio bursts (FRBs) and the redshift z of their host galaxies.
Jay Baptista +9 more
doaj +1 more source
The distribution of free electrons in the inner galaxy from pulsar dispersion measures [PDF]
The dispersion measures of a sample of 149 pulsars in the inner Galaxy (absolute value of l 50 deg) were statistically analyzed to deduce the large-scale distribution of free thermal electrons in this region. The dispersion measure distribution of these
Harding, A. K., Harding, D. S.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Impact of fragment size variability on excavator efficiency in mining operations
Технічна інженеріяThis paper examines the impact of the granulometric composition of blasted rock on the performance of excavators in mining operations. Special attention is given to the effect of fragment size distribution, specifically logarithmic dispersion, on the ...
M.V. Kachurovskyi, V.O. Sokolovskyi
doaj +1 more source
The Dispersion of Employees' Wage Increases and Firm Performance [PDF]
In this contribution we examine the interrelation between intra-firm wage increases and firm performance. Previous studies have focused on the dispersion of wages in order to examine for the empirical dominance of positive monetary incentive effects ...
Christian Grund +1 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Redshift Distributions of Fast Radio Bursts Inferred Using Clustering in Dispersion Measure Space
The Astrophysical JournalFast radio bursts (FRBs), millisecond-duration radio transient events, possess the potential to serve as excellent cosmological probes. The FRB redshift distribution contains information about the FRB sources, providing key constraints on the types of ...
Hui Peng, Yu Yu
doaj +1 more source