Results 121 to 130 of about 848,098 (285)

The electrocardiogram in hypertensive patients. P wave dispersion: a new measure to be considered

Medisur, 2010
The electrocardiogram is a complementary test with high specificity but low sensitivity. In the case of patients with arterial hypertension it is of great importance in the diagnosis, prognosis and monitoring during treatment.
Elibet Chávez González, Emilio González Rodríguez, Jesús Castro Hevia, María Del Carmen Llanes Camacho, Yosvany García Nóbrega, Raimundo Carmona Puerta, Ramiro Ramos Ramírez   +6 more
doaj   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Constraints on Evolutions of Fundamental Constants from Clustering of Fast Radio Burst Dispersion Measure

The Astrophysical Journal
Constrained measurements of fundamental physical constants using astronomical observational data represent a powerful method for investigating potential new physics. In particular, the dispersion measure (DM) of fast radio bursts (FRBs), which probes the
Shi-Yuan Wang, Jun-Qing Xia
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

On dispersion measures

Mathware & soft computing, 2001
In this paper a new framework for the study of measures of dispersion for a class of $n$-dimensional lists is proposed. The concept of monotonicity with respect to a "sharpened"-type order is introduced. This type of monotonicity, together with other well known conditions, allows to create a reasonable and general ambit where ...
Martín Pelayo, Javier, Mayor Forteza, Gaspar, Suñer Llabrés, Jaume   +2 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stellar Mass–Dispersion Measure Correlations Constrain Baryonic Feedback in Fast Radio Burst Host Galaxies

The Astrophysical Journal Letters
Low-redshift fast radio bursts (FRBs) enable robust measurements of the host galaxy contribution to the dispersion measure (DM), offering valuable constraints on the circumgalactic medium (CGM) of FRB hosts.
Calvin Leung, Sunil Simha, Isabel Medlock, Daisuke Nagai, Kiyoshi W. Masui, Lordrick A. Kahinga, Adam E. Lanman, Shion Andrew, Kevin Bandura, Alice P. Curtin, B. M. Gaensler, Nina Gusinskaia, Ronniy C. Joseph, Mattias Lazda, Lluis Mas-Ribas, Bradley W. Meyers, Kenzie Nimmo, Aaron B. Pearlman, J. Xavier Prochaska, Mawson W. Sammons, Kaitlyn Shin, Kendrick Smith, Haochen Wang, (CHIME/FRB Collaboration)   +23 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source