Results 61 to 70 of about 1,532,382 (286)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

On the Origin of the Variety of Velocity Dispersion Profiles of Galaxies

The Astrophysical Journal
Observed and simulated galaxies exhibit a significant variation in their velocity dispersion profiles. We examine the inner and outer slopes of stellar velocity dispersion profiles using integral field spectroscopy data from two surveys, SAMI (for z < 0 ...
San Han, Sukyoung K. Yi, Sree Oh, Mina Pak, Scott Croom, Julien Devriendt, Yohan Dubois, Taysun Kimm, Katarina Kraljic, Christophe Pichon, Marta Volonteri   +10 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Design of Endlessly Single Mode Photonic Crystal Fibers with Desirable Properties using HC-EDA Algorithm

Iranian Journal of Electrical and Electronic Engineering, 2015
In this article, Hill Climbing (HC) and Estimation of Distribution Algorithm (EDA) are integrated to produce a hybrid intelligent algorithm for design of endlessly Single Mode Photonic Crystal Fibers (SMPCFs) structure with desired properties over the C ...
M. Pourmahyabadi
doaj  

Reflection equalization of the simultaneous dispersion and dispersion-slope compensator based on a phase-only sampled fiber Bragg grating.

Optics Express, 2008
A novel approach for the reflection equalization of a phase-only sampled fiber Bragg grating (FBG) is presented, where the grating is specially designed as a simultaneous dispersion and dispersion-slope compensator with channels up to 51.
Ming Li, Hongpu Li
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Accurate Chromatic Dispersion Characterization of Photonic Integrated Circuits

IEEE Photonics Journal, 2012
An accurate technique to characterize chromatic dispersion and its slope versus wavelength is reported. The method is based on a heterodyne Mach-Zehnder interferometer, which is immune to thermal phase noise by using a counterpropagating reference beam ...
S. Mas, J. Matres, J. Marti, C. J. Oton
doaj   +1 more source

Reversed dispersion slope photonic bandgap fibers for broadband dispersion control in femtosecond fiber lasers

Optics Express, 2008
Higher-order-mode solid and hollow core photonic bandgap fibers exhibiting reversed or zero dispersion slope over tens or hundreds of nanometer bandwidths within the bandgap are presented. This attractive feature makes them well suited for broadband dispersion control in femtosecond pulse fiber lasers, amplifiers and optical parametric oscillators. The
Z, Várallyay, K, Saitoh, J, Fekete, K, Kakihara, M, Koshiba, R, Szipocs   +5 more
openaire   +2 more sources