Results 51 to 60 of about 2,053,587 (230)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A novel method for structural diagnosis based on passing vehicle response
Advances in Mechanical Engineering, 2017 An output-only method for structural diagnosis based on passing vehicle response is proposed in this article. Theoretical derivation reveals that the area of displacement response from only one sensor when vehicle loads pass over a bridge is in relation ...
Wan Hong +5 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A Damage Detection Algorithm Utilizing Dynamic Displacement of Bridge under Moving Vehicle
Shock and Vibration, 2016 A damage detection method is proposed, which utilizes dynamic displacement of bridge structures under moving vehicle. The problem is first elaborated with closed-form solution of dynamic displacement, which is decomposed into quasi-static component and ...
Zhen Sun +3 more
doaj +1 more source
Damage Detection in Beam Bridges Using Quasi-static Displacement Influence Lines
Applied Sciences, 2019 Quasi-static strain influence lines (ILs) based on the Brillouin optical time domain analysis (BOTDA) technique have been proposed to effectively locate damage in beam bridges.
Shaoyi Zhang, Yang Liu
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Dynamical failure index of single layer Keiwitt latticed shell structures
MATEC Web of Conferences, 2017 Based on the double control criterion of displacement and energy, a new index, dynamical damage index, for describing the dynamical damage extent in the single layer latticed shell structure is set up.
Zhu Liming +3 more
doaj +1 more source
Applied Sciences, 2020 Concrete gravity dams are one of the most common water retention structures, some of which are located in seismically active regions. Determination of damage level after earthquakes plays an important role in assessing the safety behavior of concrete ...
Xiang Lu +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source