Results 71 to 80 of about 2,053,587 (230)

Damage Model of Reinforced Concrete Members under Cyclic Loading

E3S Web of Conferences, 2018
Based on the Kumar damage model, a new damage model for reinforced concrete members is established in this paper. According to the damage characteristics of reinforced concrete members subjected to cyclic loading, four judgment conditions for determining
Wei Bo Chen, Zhang Jing Shu, Zhang Yin Hua, Zhou Jia Lai   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Development of a method for calculating effective displacement damage doses in semiconductors and applications to space field. [PDF]

PLoS One, 2022
Iwamoto Y, Sato T.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Seismic dynamic response analysis for tunnels considering coseismic displacement

Yantu gongcheng xuebao
Fault dislocation is a form of dynamic impact load that induces permanent deformation of the stratum in the vicinity of the fault. Based on the finite-fault source and crustal velocity model, coseismic displacement is computed according to the layered ...
FENG Jun1, 2 , ZHAO Boming1, 2 , WANG Zijun1, 2
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Model-Free Method for Damage Localization of Grid Structure

Applied Sciences, 2019
A model-free damage identification method for grid structures based on displacement difference is proposed. The inherent relationship between the displacement difference and the position of structural damage was deduced in detail by the Sherman− ...
Qiuwei Yang, Chaojun Wang, Na Li, Shuai Luo, Wei Wang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characterization of the energy-dependent uncertainty and correlation in silicon neutron displacement damage metrics

EPJ Web of Conferences, 2017
A rigorous treatment of the uncertainty in the underlying nuclear data on silicon displacement damage metrics is presented. The uncertainty in the cross sections and recoil atom spectra are propagated into the energy-dependent uncertainty contribution in
Griffin Patrick, Rochman Dimitri, Koning Arjan   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source