Results 11 to 20 of about 1,284,685 (310)

Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

Journal of Pharmacy & Pharmaceutical Sciences, 2016
Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles.
Nita J Patel, Enaksha Wickremsinhe, Yu-Hua Hui, Alexandar Barr, Nicholas Masterson, Kenneth Ruterbories, Jennifer Weller, Jennifer Hanes, Tom Kern, Everett Perkins   +9 more
doaj   +1 more source

Quantitation of DNA by nuclease P1 digestion and UPLC-MS/MS to assess binding efficiency of pyrrolobenzodiazepine

Journal of Pharmaceutical Analysis, 2020
Accurate DNA quantitation is a prerequisite in many biomedical and pharmaceutical studies. Here we established a new DNA quantitation method by nuclease P1 digestion and UPLC-MS/MS analysis.
Yong Ma, Buyun Chen, Donglu Zhang
doaj   +1 more source

Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

AAPS Open, 2018
Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properties ...
Maribel Beaumont, Daniela Tomazela, Douglas Hodges, Grigori Ermakov, Edward Hsieh, Isabel Figueroa, On-Yee So, Yaoli Song, Huiping Ma, Svetlana Antonenko, Wondwessen Mengesha, Yi Wei Zhang, Shuli Zhang, SuChun Hseih, Gulesi Ayanoglu, Xiaoyan Du, Eric Rimmer, Michael Judo, Franklin Vives, Jennifer H. Yearley, Christina Moon, Anthony Manibusan, Nick Knudsen, Andy Beck, Damien Bresson, Dennis Gately, Divas Neupane, Enrique Escandón   +27 more
doaj   +1 more source

The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Pharmaceutics, 2020
Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery.
Danijela Zukancic, Estelle J. A. Suys, Emily H. Pilkington, Azizah Algarni, Hareth Al-Wassiti, Nghia P. Truong   +5 more
doaj   +1 more source

Formation of Self-Assembled Mesophases During Lipid Digestion

Frontiers in Cell and Developmental Biology, 2021
Lipids play an important role in regulating bodily functions and providing a source of energy. Lipids enter the body primarily in the form of triglycerides in our diet.
Anna C. Pham, Andrew J. Clulow, Ben J. Boyd, Ben J. Boyd   +3 more
doaj   +1 more source

Necessitarianism and Dispositions [PDF]

Metaphysica, 2020
Abstract In this paper, I argue in favor of necessitarianism, the view that dispositions, when stimulated, necessitate their manifestations. After introducing and clarifying what necessitarianism does and does not amount to, I provide reasons to support the view that dispositions once stimulated necessitate their ...
openaire   +2 more sources

Temperature stability of oxytocin ampoules labelled for storage at 2°C–8°C and below 25°C: an observational assessment under controlled accelerated and temperature cycling conditions

BMJ Open, 2019
Introduction Oxytocin, administered via injection, is recommended by WHO for the prevention and treatment of postpartum haemorrhage. However, the susceptibility of oxytocin injection to thermal degradation has led WHO and UNICEF to recommend cold-chain ...
Tri-Hung Nguyen, Peter Lambert, Rajpreet Singh Minhas, Claire McEvoy, Kim Deadman, Philip Wright, Richard J Prankerd, Seloi Mogatle, Michelle P McIntosh   +8 more
doaj   +1 more source

Impact of pasteurization on the self-assembly of human milk lipids during digestion

Journal of Lipid Research, 2022
Human milk is critical for the survival and development of infants. This source of nutrition contains components that protect against infections while stimulating immune maturation.
Syaza Y. Binte Abu Bakar, Malinda Salim, Andrew J. Clulow, Adrian Hawley, Joseph Pelle, Donna T. Geddes, Kevin R. Nicholas, Ben J. Boyd   +7 more
doaj   +1 more source

Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution

Pharmaceutics, 2022
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Thomas Eason, Gisela Ramirez, Andrew J. Clulow, Malinda Salim, Ben J. Boyd   +4 more
doaj   +1 more source

Faith as an Epistemic Disposition [PDF]

, 2012
This paper presents and defends a model of religious faith as an epistemic disposition. According to the model, religious faith is a disposition to take certain doxastic attitudes toward propositions of religious significance upon entertaining certain ...
Byerly, T. Ryan
core   +1 more source