Results 31 to 40 of about 1,284,685 (310)

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

mSphere, 2016
Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line therapy. In this study, we investigated the antimicrobial activity of a novel polymyxin, FADDI-019, against Staphylococcus ...
Jinxin Zhao, Soon-Ee Cheah, Kade D. Roberts, Roger L. Nation, Philip E. Thompson, Tony Velkov, Zongjun Du, Matthew D. Johnson, Jian Li   +8 more
doaj   +1 more source

Le numérique comme objet intellectuel

Interfaces Numériques, 2021
L’article prend à rebours la notion de représentations du numérique pour considérer le numérique comme une représentation, sociosémiotiquement construite et qui détermine le rapport du sujet à son environnement en termes de perception, de conception et ...
Julien Péquignot
doaj   +1 more source

Images Avant la Lettre. The Mystery of Ink Blots in Psychology, Design and Art

img journal, 2023
The paper starts out with a figure of speech –avant la lettre– and points, through a review of literature, to a variety of disciplinary explanations regarding processes before language was ever spoken.
Michael Renner
doaj   +1 more source

Against Extrinsic Dispositions [PDF]

, 2017
McKitrick (2003) proposes that an object has a disposition if and only if there are a manifestation, the circumstances of the manifestation, a counterfactual true of the object, and an overtly dispositional locution referring to the disposition.
Park, Seungbae
core   +1 more source

The Identity of Dispositions

, 2018
Clear criteria for the identity of dispositions are still lacking, and this has been presented as one of the main challenge raised by such entities. It is of prime importance to identify or distinguish dispositions such as diseases or risks. This article first introduces conventional ways to refer to a disposition (such as “fragility& ...
Adrien Barton, Olivier Grenier, Ludger Jansen, Jean-François Ethier   +3 more
openaire   +3 more sources

Lymphatic uptake and pharmacokinetics of lipid conjugated brush PEG polymers is altered by interactions with albumin and lipoproteins

Frontiers in Physiology
IntroductionIncreased recognition of the role of lymphatics in disease has brought increased focus on the design of lymph-directed delivery systems for imaging agents and therapeutics.
Mohammad Abdallah, Ian K. Styles, Alexander Mörsdorf, James L. Grace, John F. Quinn, John F. Quinn, Michael R. Whittaker, Natalie L. Trevaskis, Natalie L. Trevaskis   +8 more
doaj   +1 more source

Design and Evaluation of Novel Polymyxin Fluorescent Probes

Sensors, 2017
Polymyxins (polymyxin B and colistin) are cyclic lipopeptide antibiotics that serve as a last-line defence against Gram-negative “superbugs”. In the present study, two novel fluorescent polymyxin probes were designed through regio-selective modifications
Bo Yun, Kade D. Roberts, Philip E. Thompson, Roger L. Nation, Tony Velkov, Jian Li   +5 more
doaj   +1 more source

Immunogenicity assessment strategy for a chemically modified therapeutic protein in clinical development

Frontiers in Immunology
The clinical immunogenicity assessment for complex multidomain biological drugs is challenging due to multiple factors that must be taken into consideration.
Charlotte Hagman, Gaetan Chasseigne, Robert Nelson, Florian Anlauff, Mark Kagan, Allison B. Goldfine, Grzegorz Terszowski, Maria Jadhav   +7 more
doaj   +1 more source

The Kinetics of De-agglomeration of Magnesium Stearate Dry-Coated Salbutamol Sulphate Powders

KONA Powder and Particle Journal, 2014
The objective was to investigate the effect of dry coating of salbutamol sulphate (SS) with magnesium stearate (MgSt) on the kinetics of powder de-agglomeration.
Jiani Shi, Shyamal Das, David Morton, Peter Stewart   +3 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source