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Cotinine disposition and effects
Clinical Pharmacology and Therapeutics, 1983Cotinine is the major metabolite of nicotine in man. We studied cotinine disposition kinetics in 28 healthy habitual cigarette smokers. Eight subjects received cotinine fumarate, 4 micrograms base/kg/min IV for 60 min. Mean (+/- SD) metabolic clearance was 60 +/- 12 ml/min and mean renal clearance was 12 +/- 5 ml/min, averaging 17% of total clearance ...
N L, Benowitz +4 more
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Effects of Age on Meperidine Disposition
Survey of Anesthesiology, 1985Elderly patients appear to be more sensitive to meperidine than younger ones; however, the contributions of altered dynamic and kinetic factors are not clear. Accordingly, seven healthy normal men aged 60 to 79 yr were simultaneously given 25 mg meperidine HCl intravenously and the same dose of deuterium-labeled drug either orally or intramuscularly ...
R J, Herman +3 more
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Determinants of Disposition and Reverse Disposition Effects
SSRN Electronic Journal, 2009We develop a new measure for disposition effects based on the average length of a trading strategy and whether it is loss-making or profitable. Using this new measure, we are able to evaluate disposition effects in more detail than has been possible previously. We find for the first time the existence of disposition and reverse disposition effects. The
Andreas Krause +2 more
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Effect of Ranitidine on Bupivacaine Disposition
Anesthesia & Analgesia, 1991This study was undertaken to determine the effect, if any, of ranitidine on bupivacaine disposition in 28 women undergoing cesarean section. Before epidural anesthesia, ranitidine (50 mg IM) or sodium citrate (30 mL orally) was administered to groups of 14 parturients each.
W T, Brashear +4 more
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Effect of cimetidine on verapamil disposition
Clinical Pharmacology and Therapeutics, 1985The effects of multiple doses of cimetidine on single-dose verapamil kinetics were studied in nine healthy men. Baseline hepatic blood flow was estimated by indocyanine green elimination on day 1. On day 2, the subjects received verapamil, 10 mg iv, after which the plasma concentration-time profile was determined. After a 2-day washout, cimetidine, 300
C M, Loi +3 more
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Mexiletine effects on theophylline disposition
Clinical Pharmacology and Therapeutics, 1991The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days.
A, Hurwitz +5 more
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Disposition kinetics and effects of menthol
Clinical Pharmacology & Therapeutics, 1999Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure ...
Yu, L +3 more
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Effect of Rifampin on Theophylline Disposition
Therapeutic Drug Monitoring, 1984The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin administration (600 mg/day) in six healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 +/- 21.2 to 68.9 +/- 26.5 ml/h/kg.
A B, Straughn +3 more
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