Results 301 to 310 of about 750,066 (346)
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SSRN Electronic Journal, 2009
The paper examines the tendency to sell winners and hold on to losers in a dynamic noisy rational expectations equilibrium with informed and uninformed investors. The key feature of the model is that the information asymmetry between investors varies over time. Besides demonstrating that the disposition effect is not intrinsically at odds with rational
Daniel Dorn, Günter Strobl
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The paper examines the tendency to sell winners and hold on to losers in a dynamic noisy rational expectations equilibrium with informed and uninformed investors. The key feature of the model is that the information asymmetry between investors varies over time. Besides demonstrating that the disposition effect is not intrinsically at odds with rational
Daniel Dorn, Günter Strobl
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Mexiletine effects on theophylline disposition
Clinical Pharmacology and Therapeutics, 1991The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days.
A, Hurwitz +5 more
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Effects of Age on Meperidine Disposition
Survey of Anesthesiology, 1985Elderly patients appear to be more sensitive to meperidine than younger ones; however, the contributions of altered dynamic and kinetic factors are not clear. Accordingly, seven healthy normal men aged 60 to 79 yr were simultaneously given 25 mg meperidine HCl intravenously and the same dose of deuterium-labeled drug either orally or intramuscularly ...
R J, Herman +3 more
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Effect of cimetidine on verapamil disposition
Clinical Pharmacology and Therapeutics, 1985The effects of multiple doses of cimetidine on single-dose verapamil kinetics were studied in nine healthy men. Baseline hepatic blood flow was estimated by indocyanine green elimination on day 1. On day 2, the subjects received verapamil, 10 mg iv, after which the plasma concentration-time profile was determined. After a 2-day washout, cimetidine, 300
C M, Loi +3 more
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Effect of Ranitidine on Bupivacaine Disposition
Anesthesia & Analgesia, 1991This study was undertaken to determine the effect, if any, of ranitidine on bupivacaine disposition in 28 women undergoing cesarean section. Before epidural anesthesia, ranitidine (50 mg IM) or sodium citrate (30 mL orally) was administered to groups of 14 parturients each.
W T, Brashear +4 more
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Effect of Rifampin on Theophylline Disposition
Therapeutic Drug Monitoring, 1984The concentrations of theophylline from single 400-mg oral doses were evaluated both before and after 7 days of oral rifampin administration (600 mg/day) in six healthy, nonsmoking adults. The mean oral clearance of theophylline was significantly increased from 54.9 +/- 21.2 to 68.9 +/- 26.5 ml/h/kg.
A B, Straughn +3 more
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Disposition kinetics and effects of menthol
Clinical Pharmacology & Therapeutics, 1999Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study that compared pure menthol versus placebo, along with an uncontrolled exposure ...
Yu, L +3 more
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Effect of smoking on theophylline disposition
Clinical Pharmacology & Therapeutics, 1976The pharmacokinetics of theophylline were examined in a group of nonsmokers and in heavy smokers (1 to 2 packs/day) before and 3 to 4 mo after cessation of cigarette smoking. The half‐life of theophylline in smokers averaged 4.3 (SD = 1.4) hr, significantly shorter than the mean value in nonsmokers (7.0, SD = 1.7 hr).
S N, Hunt, W J, Jusko, A M, Yurchak
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Effect of alcohol on propylthiouracil disposition
Clinical Pharmacology and Therapeutics, 1983We examined the effect of ethanol on propylthiouracil (PTU) disposition in normal subjects and a rabbit. The drug is metabolized by conjugation. In six normal subjects 19.2 gm oral ethanol, taken either with or two hr after 300 mg PTU, did not change maximum concentration, time to maximum concentration, or total or free AUC of PTU.
J P, Long +6 more
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Aging effects on drug disposition and effect
Geriatric Nephrology and Urology, 1999Drug therapy in older individuals has generally been summarized in the phrase "start low and go slow". As better understanding of the effects and disposition of drugs in the aged has evolved, the concept of "therapeutic burden" which encompasses the number of concurrent medications as well as the dose of medications administered has assumed ...
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