Results 41 to 50 of about 755,225 (345)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

The Investigation of Maximum and Minimum Stock Price’s Effects as Reference Point on Volume in Tehran Stock Exchange [PDF]

Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2011
One of the new approach in finance literature is behavioral finance, that describes behavior of investors and satisfies some of the anomalies that effective market hypothesizes were not able to describe it.
Hassan Ghalibaf Asl, Mohsen Sadeghi Batani   +1 more
doaj  

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

The Flow–Performance Relationship and Behavioral Biases: Evidence from Spanish Mutual Fund Flows

Risks
This study analyzes the relationship between stock market returns and investment flows in investment funds in Spain. Through a quantitative analysis covering the period from December 2001 to June 2025, it examines not only the existence of a correlation ...
Carlos Arenas-Laorga, Fernando Gil Capella   +1 more
doaj   +1 more source

Postgraduates’ time management disposition and mental health: mediating role of life satisfaction and moderating role of core self-evaluations

BMC Psychology, 2023
Background The current study aimed to investigate the relationship between postgraduates’ time management disposition and mental health. As such, it constructed a moderated mediation model to examine the mediating role of life satisfaction on the ...
Shen Liu, Minghua Song, Han Teng
doaj   +1 more source

Artificial Intelligence‐based Online Symptom Assessment Tools for Systemic Lupus Erythematosus (SLE) diagnosis: Patient Perspectives

Arthritis Care &Research, Accepted Article.
Objective The objective of this article is to identify perceptions of SLE patients regarding artificial intelligence (AI)‐based online symptom assessment tools, and the potential of these tools to address diagnostic barriers. Methods Adults from our SLE research cohort were invited to participate in 60‐90 minute virtual focus groups concerning their ...
Olivia A. Stein, Jennifer LF. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source

How can Multi-Agents AI Systems help Reduce Biases in Trading Algorithms? [PDF]

Revista de Management Comparat International
Algorithmic trading is now the most common form of trading in financial markets, and it has been estimated that it accounts for 60-75% of the total trading volume in major markets.
Florin GROSU
doaj   +1 more source

EFFECT OF METHYLENE BLUE ON THE DISPOSITION OF ETHANOL [PDF]

Alcohol and Alcoholism, 2000
The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol ...
Vonlanthen, Ronald, Beer, Jürg H., Lauterburg, Bernhard H.   +2 more
openaire   +4 more sources

Exploring the Impact of Supervision on Pretrial Outcomes [PDF]

, 2013
This study seeks to investigate the effect of pretrial supervision on the likelihood of failure to appear (FTA) and new criminal activity (NCA) before case disposition.
Christopher T. Lowenkamp, Marie Van Nostrand   +1 more
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