Results 181 to 190 of about 170,789 (315)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Risk factors and management of medical disputes: An analysis of preliminary appraisal reports. [PDF]

PLoS One
Chang CT, Liaw YP.
europepmc   +1 more source

Badge Dispute At Aircraft Plant

, 1953
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about a labor dispute over unionized aircraft workers being refused admittance to the Chance Vought Aircraft Company in Grand Prairie for placing union signs on their ...
WBAP-TV (Television station : Fort Worth, Tex.)
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multimodal deep learning for international investment arbitration outcome prediction and bilateral investment agreement negotiation strategy optimization. [PDF]

Sci Rep
Wu H, Xu J.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Characteristics of exonerated cases of child sexual abuse. [PDF]

Front Psychol
Denne E, Sullivan CE, Neal TMS.
europepmc   +1 more source

Costs and Benefits of a WTO Dispute: Philippine Bananas and the Australian Market

Why do governments engage in WTO disputes? What can countries expect to gain from international legal trade battles? This article examines the costs and benefits of the Philippine-Australian dispute regarding Australia's quarantine policy on Philippine ...
Schmitz, Andrew, Javelosa, Josyline C.
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

AI and digital justice in EU labor law. A comparative study on predictive tools and judicial transformation. [PDF]

Front Artif Intell
Molinari M, Giacalone M.
europepmc   +1 more source