Results 51 to 60 of about 27,347 (299)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Body‐Self Unity With a New Hip or Knee: Understanding Total Joint Replacement Within an Embodiment Framework

ACR Open Rheumatology, 2019
Medical research increasingly makes use of embodiment concepts to understand how illness disrupts unity of body and self. However, few have applied embodiment concepts in total joint replacement (TJR), an effective treatment for end‐stage arthritis.
Emma C. Lape, Pamela Hudak, Aileen M. Davis, Jeffrey N. Katz   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Spain, and the Crisis of Investment Arbitration: Extra-EU Jurisdictions as Alternative enforcement Forums

Behavior & Law Journal
The purpose of this paper is to examine the structural crisis that currently faces the international investment arbitration regime within the European Union, with particular attention to the growing incompatibility between the Energy Charter Treaty (ECT)
Jesús Alfonso Soto Pineda, Evelyn Gacitúa, Fernando González, Elena Lucas   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluating Community Violence Intervention Programs: A Scoping Review Synthesizing Methods and Measures

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Community violence intervention (CVI) is a promising strategy to reduce community violence, but research on CVI programs remains underdeveloped. While prior reviews have examined the effectiveness of certain CVI models, we lack a comprehensive synthesis ...
Meron Girma MPH, Julia Schleimer MPH, PhD, Astrid Aveledo MPA, Ayah Mustafa BA, Camerin Rencken MPH, PhD, Carolyn Thurston MA, Deepika Nehra MD, Kris Torset BA, Kristian Jones MA, PhD, Laura Johnson MSW, Lauren Polansky MLS, MPH, Olivia McCollum MPH, Orlando Ames AA, Rachel Ross MPH, Sam Decker MBA, Stephanie Taylor MPA, Tarrell Harrison BAS, Vivian Lyons MPH, PhD, Zaheed Lynch BA, Ali Rowhani-Rahbar MPH, MD, PhD   +19 more
doaj   +1 more source

Judicial Dispute Resolution in Canada: Towards Accessible Dispute Resolution

The Windsor Yearbook of Access to Justice, 2018
This article argues that access to judges is an essential element of access to justice. Traditional civil litigation procedure aimed at preparation for trial that is complex, time-consuming and costly obstructs such access, especially for litigants ...
Archie Zariski
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Apologies, Mediation and the Law: Resolution of Civil Disputes

Oñati Socio-Legal Series, 2016
Mediation is a process that provides opportunities for parties to civil disputes to engage in dialogue that can satisfy their expectations and needs for apologies.
Robyn Carroll, Alfred Allan, Margaret Halsmith   +2 more
doaj