Results 61 to 70 of about 469,149 (345)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Spain, and the Crisis of Investment Arbitration: Extra-EU Jurisdictions as Alternative enforcement Forums

Behavior & Law Journal
The purpose of this paper is to examine the structural crisis that currently faces the international investment arbitration regime within the European Union, with particular attention to the growing incompatibility between the Energy Charter Treaty (ECT)
Jesús Alfonso Soto Pineda, Evelyn Gacitúa, Fernando González, Elena Lucas   +3 more
doaj   +1 more source

Body‐Self Unity With a New Hip or Knee: Understanding Total Joint Replacement Within an Embodiment Framework

ACR Open Rheumatology, 2019
Medical research increasingly makes use of embodiment concepts to understand how illness disrupts unity of body and self. However, few have applied embodiment concepts in total joint replacement (TJR), an effective treatment for end‐stage arthritis.
Emma C. Lape, Pamela Hudak, Aileen M. Davis, Jeffrey N. Katz   +3 more
doaj   +1 more source

Control Over Dispute-System Design and Mandatory Commercial Arbitration [PDF]

, 2004
This article argues that mandatory arbitration is not itself the problem. The problem is instead that in some instances, one party to the dispute has exclusive control of the design of the dispute-resolution system.
Bingham, Lisa B.
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Evaluating Community Violence Intervention Programs: A Scoping Review Synthesizing Methods and Measures

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Community violence intervention (CVI) is a promising strategy to reduce community violence, but research on CVI programs remains underdeveloped. While prior reviews have examined the effectiveness of certain CVI models, we lack a comprehensive synthesis ...
Meron Girma MPH, Julia Schleimer MPH, PhD, Astrid Aveledo MPA, Ayah Mustafa BA, Camerin Rencken MPH, PhD, Carolyn Thurston MA, Deepika Nehra MD, Kris Torset BA, Kristian Jones MA, PhD, Laura Johnson MSW, Lauren Polansky MLS, MPH, Olivia McCollum MPH, Orlando Ames AA, Rachel Ross MPH, Sam Decker MBA, Stephanie Taylor MPA, Tarrell Harrison BAS, Vivian Lyons MPH, PhD, Zaheed Lynch BA, Ali Rowhani-Rahbar MPH, MD, PhD   +19 more
doaj   +1 more source

Regulation of Dispute Resolution in the United States of America: From the Formal to the Informal to the ‘Semi-formal’ [PDF]

, 2013
The story of ADR in the US is one of ‘co-optation’ of what was to be a serious challenge to formalistic and legalistic approaches to legal and social problem solving and is now highly institutionalized by its more formal use in courts.
Menkel-Meadow, Carrie
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Judicial Dispute Resolution in Canada: Towards Accessible Dispute Resolution

The Windsor Yearbook of Access to Justice, 2018
This article argues that access to judges is an essential element of access to justice. Traditional civil litigation procedure aimed at preparation for trial that is complex, time-consuming and costly obstructs such access, especially for litigants ...
Archie Zariski
doaj   +1 more source