Results 121 to 130 of about 4,594 (295)
LdoD Visual - A Visual Reader for Fernando Pessoa’s Book of Disquiet: An In-Out- In Metaphor
, 2021 There is an increasing use of information visualization techniques in Digital Humanities to support the analysis of literary works. On the other hand, the rise of digital reading on the web as well as the development of dedicated e-book readers has ...
Rito Silva, António +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
An Unwritten Novel – Fernando Pessoa’s The Book of Disquiet, de Thomas J. Cosineau [PDF]
, 2015 UID/ELT/00657/2013Recensão crítica do ensaio, de Thomas J. Cosineau, “An Unwritten Novel – Fernando Pessoa’s The Book of Disquiet”. O ensaio parte da seguinte afirmação de Bernardo Soares: “Qualquer coisa, conforme se considera, é um assombro ou um ...
Freitas, Ana Maria de Almeida Pires
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Organ donation after euthanasia starting with anesthesia at home is legal in The Netherlands, Belgium, Canada and Spain. [PDF]
BMC Med Ethics, 2023 Mulder J, Sonneveld H.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
One danger and eleven types of academic disquiet whilst hunting for cinematic Christ-figures
, 2020 Christ-figures increasingly permeate the popular cinema, but hunting for them is not necessarily a benign or unproblematic activity. Following a selective review of the film and religion literature, and a preliminary scan of the popular cinema utilizing ...
Anton Karl Kozlovic (13057347)
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