Results 71 to 80 of about 401,655 (316)

Pupillary dynamics of mice performing a Pavlovian delay conditioning task reflect reward-predictive signals

Frontiers in Systems Neuroscience, 2022
Pupils can signify various internal processes and states, such as attention, arousal, and working memory. Changes in pupil size have been associated with learning speed, prediction of future events, and deviations from the prediction in human studies ...
Kota Yamada, Kota Yamada, Koji Toda
doaj   +1 more source

Remnant baryon mass outside of the black hole after a neutron star-black hole merger [PDF]

, 2018
Gravitational-wave (GW) and electromagnetic (EM) signals from the merger of a Neutron Star (NS) and a Black Hole (BH) are a highly anticipated discovery in extreme gravity, nuclear-, and astrophysics.
Foucart, Francois, Hinderer, Tanja, Nissanke, Samaya   +2 more
core   +5 more sources

Disrupted sensorimotor predictions in high autistic characteristics

Proceedings of the National Academy of Sciences
Humans maintain a stable view of the world by omitting self-generated motion during rapid eye movements, or saccades. An efferent copy of the saccade motor command informs visual processing about the self-produced motion. However, efference copy information has been demonstrated to be disrupted in individuals with high autistic traits.
Antonella Pomè, Eckart Zimmermann
openaire   +2 more sources

Predicting nsSNPs that Disrupt Protein-Protein Interactions Using Docking [PDF]

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2017
The human genome contains a large number of protein polymorphisms due to individual genome variation. How many of these polymorphisms lead to altered protein-protein interaction is unknown. We have developed a method to address this question. The intersection of the SKEMPI database (of affinity constants among interacting proteins) and CAPRI 4.0 ...
Goodacre, Norman, Edwards, Nathan, Danielsen, Mark, Uetz, Peter, Wu, Cathy H.   +4 more
openaire   +3 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Implementing deep learning-based disruption prediction in a drifting data environment of new tokamak: HL-3

Nuclear Fusion
A deep learning-based disruption prediction algorithm has been implemented on a new tokamak, HL-3. An Area Under receiver-operator characteristic Curve of 0.940 has been realized offline over a test campaign involving 72 disruptive and 240 non-disruptive
Zongyu Yang, Wulyu Zhong, Fan Xia, Zhe Gao, Xiaobo Zhu, Jiyuan Li, Liwen Hu, Zhaohe Xu, Da Li, Guohui Zheng, Yihang Chen, Junzhao Zhang, Bo Li, Xiaolong Zhang, Yiren Zhu, Ruihai Tong, Yunbo Dong, Yipo Zhang, Boda Yuan, Xin Yu, Zongyuhui He, Wenjing Tian, Xinwen Gong, Min Xu   +23 more
doaj   +1 more source

Tokamak plasma disruption precursor onset time study based on semi-supervised anomaly detection

Nuclear Engineering and Technology
Plasma disruption in tokamak experiments is a challenging issue that causes damage to the device. Reliable prediction methods are needed, but the lack of full understanding of plasma disruption limits the effectiveness of physics-driven methods.
X.K. Ai, W. Zheng, M. Zhang, D.L. Chen, C.S. Shen, B.H. Guo, B.J. Xiao, Y. Zhong, N.C. Wang, Z.J. Yang, Z.P. Chen, Z.Y. Chen, Y.H. Ding, Y. Pan   +13 more
doaj   +1 more source

Uniaxial stretch-induced axonal injury thresholds for axonal dysfunction and disruption and strain rate effects on thresholds for mouse neuronal stem cells

Journal of Biomechanical Science and Engineering, 2017
In this paper, the proposed study aims to achieve a better understanding of neuronal tolerance and contribute to the prediction of the secondary degeneration of diffuse axonal injury (DAI). Therefore, a uniaxial stretching device which subjected cultured
Evrim KURTOGLU, Hiromichi NAKADATE, Kazuhiro KIKUTA, Shigeru AOMURA, Akira KAKUTA   +4 more
doaj   +1 more source

Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia [PDF]

, 2017
Published in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding ...
Ford, Judith M., Gunduz-Bruce, Handan, Jaeger, Judith, Kort, Naomi S., Krystal, John H., Mathalon, Daniel H., Reinhart, Robert M.G., Roach, Brian J.   +7 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source