Results 51 to 60 of about 138,109 (218)

From cold start to sustainable operation: a strategy for disruption prediction across the tokamak lifecycle

Nuclear Fusion
Plasma disruption is a significant challenge in tokamak fusion, especially in large-size future devices like ITER, where it causes severe damage. Safeguarding future tokamaks throughout their entire lifecycle demands a disruption prediction strategy that
Xinkun Ai, Zhong Yu, Wei Zheng, Ming Zhang, Yonghua Ding, Zhongyong Chen, Dalong Chen, Bihao Guo, Chengshuo Shen, Nengchao Wang, Yuan Pan, Bingjia Xiao, Biao Shen, J-TEXT team   +13 more
doaj   +1 more source

Dropout in Neural Networks Simulates the Paradoxical Effects of Deep Brain Stimulation on Memory

Frontiers in Aging Neuroscience, 2020
Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia.
Shawn Zheng Kai Tan, Richard Du, Jose Angelo Udal Perucho, Shauhrat S. Chopra, Varut Vardhanabhuti, Lee Wei Lim   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Decoding density limit disruption precursor patterns in J-TEXT using interpretable machine learning

Nuclear Fusion
Achieving high-density operation is crucial for maximizing the fusion gain factor in future tokamaks. While the Greenwald density limit is widely used, it lacks a first-principles basis and its underlying physics remains under discussion. Recent research
Wei Zheng, Mingqiao Wen, Chengshuo Shen, Li Gao, Weijie Lin, Runyu Luo, Fengming Xue, Yonghua Ding, Zhongyong Chen, J-TEXT Team   +9 more
doaj   +1 more source

Machine Learning for Plasma Disruption Prediction in TCABR

IEEE Access
Plasma disruptions are one of the most critical challenges in tokamak operations, as they can severely damage reactor components and compromise fusion performance.
Vinicius M. Neto, Felipe V. De Almeida, Wanderley P. De Sa, Jose H. F. Severo   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months

NeuroImage: Clinical, 2018
Objective: Functional connectivity magnetic resonance imaging (fcMRI) of neonates with perinatal brain injury could improve prediction of motor impairment before symptoms manifest, and establish how early brain organization relates to subsequent ...
Annika C. Linke, Conor Wild, Leire Zubiaurre-Elorza, Charlotte Herzmann, Hester Duffy, Victor K. Han, David S.C. Lee, Rhodri Cusack   +7 more
doaj   +1 more source