Results 71 to 80 of about 407,221 (296)

Using transcranial direct-current stimulation (tDCS) to understand cognitive processing [PDF]

, 2016
Noninvasive brain stimulation methods are becoming increasingly common tools in the kit of the cognitive scientist. In particular, transcranial direct-current stimulation (tDCS) is showing great promise as a tool to causally manipulate the brain and ...
Cosman, Josh D., Fukuda, Keisuke, Reinhart, Robert M.G., Woodman, Geoffrey F.   +3 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Implementing deep learning-based disruption prediction in a drifting data environment of new tokamak: HL-3

Nuclear Fusion
A deep learning-based disruption prediction algorithm has been implemented on a new tokamak, HL-3. An Area Under receiver-operator characteristic Curve of 0.940 has been realized offline over a test campaign involving 72 disruptive and 240 non-disruptive
Zongyu Yang, Wulyu Zhong, Fan Xia, Zhe Gao, Xiaobo Zhu, Jiyuan Li, Liwen Hu, Zhaohe Xu, Da Li, Guohui Zheng, Yihang Chen, Junzhao Zhang, Bo Li, Xiaolong Zhang, Yiren Zhu, Ruihai Tong, Yunbo Dong, Yipo Zhang, Boda Yuan, Xin Yu, Zongyuhui He, Wenjing Tian, Xinwen Gong, Min Xu   +23 more
doaj   +1 more source

Tokamak plasma disruption precursor onset time study based on semi-supervised anomaly detection

Nuclear Engineering and Technology
Plasma disruption in tokamak experiments is a challenging issue that causes damage to the device. Reliable prediction methods are needed, but the lack of full understanding of plasma disruption limits the effectiveness of physics-driven methods.
X.K. Ai, W. Zheng, M. Zhang, D.L. Chen, C.S. Shen, B.H. Guo, B.J. Xiao, Y. Zhong, N.C. Wang, Z.J. Yang, Z.P. Chen, Z.Y. Chen, Y.H. Ding, Y. Pan   +13 more
doaj   +1 more source

Sleep, circadian system and traumatic stress

European Journal of Psychotraumatology, 2021
The human circadian system creates and maintains cellular and systemic rhythmicity essential for the temporal organization of physiological processes promoting homeostasis and environmental adaptation.
Agorastos Agorastos, Miranda Olff
doaj   +1 more source

A Bayesian inference approach for determining player abilities in football

, 2020
We consider the task of determining a football player's ability for a given event type, for example, scoring a goal. We propose an interpretable Bayesian model which is fit using variational inference methods.
Edwards, Daniel, Kosmidis, Ioannis, Silva, Ricardo, Whitaker, Gavin A.   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Real-time disruption prediction in multi-dimensional spaces leveraging diagnostic information not available at execution time

Nuclear Fusion
This article describes the use of privileged information to train supervised classifiers, applied for the first time to the prediction of disruptions in tokamaks.
J. Vega, S. Dormido-Canto, R. Castro, J.D. Fernández, A. Murari, JET Contributors   +5 more
doaj   +1 more source

Uniaxial stretch-induced axonal injury thresholds for axonal dysfunction and disruption and strain rate effects on thresholds for mouse neuronal stem cells

Journal of Biomechanical Science and Engineering, 2017
In this paper, the proposed study aims to achieve a better understanding of neuronal tolerance and contribute to the prediction of the secondary degeneration of diffuse axonal injury (DAI). Therefore, a uniaxial stretching device which subjected cultured
Evrim KURTOGLU, Hiromichi NAKADATE, Kazuhiro KIKUTA, Shigeru AOMURA, Akira KAKUTA   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source