Results 71 to 80 of about 140,191 (290)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Predictable Patterns of Disruptive Selection in Stickleback in Postglacial Lakes [PDF]
The American Naturalist, 2008 Disruptive selection is often assumed to be relatively rare, because it is dynamically unstable and hence should be transient. However, frequency-dependent interactions such as intraspecific competition may stabilize fitness minima and make disruptive selection more common.
Bolnick, Daniel I., Lau, On Lee
openaire +3 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Dropout in Neural Networks Simulates the Paradoxical Effects of Deep Brain Stimulation on Memory
Frontiers in Aging Neuroscience, 2020 Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia.
Shawn Zheng Kai Tan +5 more
doaj +1 more source
A Novel Improved Grey Incidence Model for Evaluating the Performance of Supply Chain Resilience
Discrete Dynamics in Nature and Society, 2023 Under uncertain conditions, stronger supply chain resilience can effectively reduce disruption risks and help enterprises achieve their goal of high-quality operations.
Feipeng Huang
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An interpretable disruption predictor on EAST using improved XGBoost and SHAP
Nuclear FusionThe development of a disruption predictor using a data-driven solution is an effective way to avoid or mitigate tokamak device disruptions. The black-box nature of the model itself determines the agnostic nature of its decision base and becomes a key ...
D.M. Liu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A PREDICTION TOOL FOR REAL-TIME APPLICATION IN THE DISRUPTION PROTECTION SYSTEM AT JET [PDF]
, 2007 A disruption prediction system, based on neural networks, is presented in this paper. The system is ideally suitable for on-line application in the disruption avoidance and/or mitigation scheme at the JET tokamak. A multi-layer perceptron (MLP) predictor
ZEDDA, MARIA KATIUSCIA +8 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source