Results 71 to 80 of about 138,109 (218)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Frontiers in PhysicsIntroduction: This work explores the use of eXplainable artificial intelligence (XAI) to analyze a convolutional neural network (CNN) trained for disruption prediction in tokamak devices and fed with inputs composed of different physical quantities ...
L. Bonalumi +11 more
doaj +1 more source
A Review of Traditional and Data-Driven Approaches for Disruption Prediction in Different Tokamaks [PDF]
E3S Web of ConferencesTokamak is a nuclear fusion reactor; inside, the two lighter nuclei known as deuterium and tritium are first ionized together to form plasma, which is heated up to 150 million degrees Celsius, and then they are confined by the torus-shaped magnetic field.
Priyanka M., Sangeetha J., Jayakumar C.
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
An investigation of factors influencing disrupted sleep in university students
فصلنامه دانشگاه علوم پزشکی جهرم, 2013 Introduction: Sleep disruption is one of the psychosocial issues among college students which might adversely affect their lives. This study examines the role of individual and psychosocial factors and intensive scholastic schedule in disrupted sleep ...
Ishagh Rahimian Boogar +1 more
doaj
Machine learning based disruption prediction using long short-term memory in KSTAR
Nuclear FusionThis study presents a machine learning model for predicting plasma disruptions using the KSTAR database. The model employs a long short-term memory (LSTM) network to capture temporal patterns in zero-dimensional plasma signals.
Jeongwon Lee +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Astrophysical Journal LettersSupermassive black hole (SMBH) growth plausibly occurs via runaway astrophysical black hole mergers in nuclear star clusters that form intermediate mass black hole seeds at high redshifts.
Konstantinos Kritos, Joseph Silk
doaj +1 more source
Machine Learning Models for Estrogen Receptor Bioactivity and Endocrine Disruption Prediction. [PDF]
Environ Sci Technol, 2020 Zorn KM +9 more
europepmc +1 more source