Results 41 to 50 of about 140,191 (290)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Disruption Prediction Approaches Using Machine Learning Tools in Tokamaks [PDF]
Nuclear fusion is one of the best options to achieve a virtually limitless energy source in the future. However, sustaining burning plasma reactions is very challenging because disruptive events cause the loss of plasma confinement and damages to the ...
Cannas, B. +5 more
core +2 more sources
Balancing physics priors and data for disruption prediction in future tokamaks
Nuclear FusionDisruption remains a major barrier to the safe, sustained operation of tokamaks. Although current understanding of disruption physics is broadly valid across existing tokamaks, it cannot provide accurate disruption prediction rules.
Fengming Xue +11 more
doaj +1 more source
Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia. [PDF]
PLoS ONE, 2012 The following study used 3-T functional magnetic resonance imaging (fMRI) to investigate the neural signature of Kamin blocking. Kamin blocking is an associative learning phenomenon seen where prior association of a stimulus (A) with an outcome blocks ...
Paula M Moran +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
High-beta disruption prediction study on HL-2A with instance-based transfer learning
Nuclear FusionUnmitigated disruptions pose a much more serious threat when large-scale tokamaks are operating in the high performance regime. Machine learning based disruption predictors can exhibit impressive performance.
Y. Zhong +15 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Disruption prediction at JET [PDF]
, 1998 The sudden loss of the plasma magnetic confinement, known as disruption, is one of the major issue in a nuclear fusion machine as JET (Joint European Torus). Disruptions pose very serious problems to the safety of the machine.
Milani, F.
core
Design and development of an off-normal warning system for SPARC
Nuclear FusionThe SPARC tokamak is a compact, high-field, and high-current device that will rely on disruption mitigation and prevention strategies to address the risks associated with its high stored energy densities.
A.R. Saperstein +6 more
doaj +1 more source