Results 161 to 170 of about 193,431 (315)

Nanotechnology and business opportunities: scenarios as awareness instrument [PDF]

For a few years now, nanotechnology has been recognised as a promising new growth innovator. This leads to a shift from the exploration of nanotechnology knowledge towards a phase of exploitation. The coming years this commercialisation of nanotechnology
WHC Knol
core  

Canal Construction Disrupts Camouflage in Two Sympatric Estuarine Crab Species. [PDF]

Ecol Evol
Huang Y, Lu S, Lai F, Zhai B, Liao Y, Wang H, Bu R.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

What are the most disruptive publications in shoulder surgery? [PDF]

JSES Int
Khawaja SR, Balaji S, Hryc C, Elkousy HA, Gottschalk MB, Warner JJP, Wagner ER, Edwards TB.   +7 more
europepmc   +1 more source

Disruptive Innovations [PDF]

Disaster Medicine and Public Health Preparedness, 2015
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploiting a Disruptive Technology to Actively Engage Students in the Learning Process

, 2013
Once every decade or so, a disruptive technology appears that has the potential to revolutionize electrical and computer engineering (ECE) education. This paper considers the impact of one of the most recent examples: a USB-powered instrument called ...
Meehan, Kathleen, Connor, Kenneth A., Mercer, Douglas A., Robertson, John M., Bowman, Robert John   +4 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Marijuana-tourism: Disruptive Innovation for Small Island Developing States

, 2018
The Caribbean region consists of many small island developing states (SIDS) that are dependent on a sun, sea, and sand (3-S) tourism product. These SIDS are facing declining competitiveness vis-à-vis other tourism destinations and need to differentiate ...
Wenner, Gemma Antonine
core  

Disruptive behavior in preschoolers: associations with attention deficit hyperactivity disorder and parental psychopathology. [PDF]

BMC Psychiatry
Arı P, Büber A, Şenol H.
europepmc   +1 more source