Results 71 to 80 of about 349,129 (300)

Youth Academic Success:It Starts in the Home [PDF]

open access: yes, 2020
Academic Success of youth is critical for their future success as well as for the economic and social health of their communities. Using a mixed methods approach (the 2008-2013 “Social Capital and Children’s Development” survey and commentaries of eight ...
Ybarra, Veronica Fay
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Seriousness, Irony, and Cultural Politics: A Defense of Jorge Portilla [PDF]

open access: yes, 2013
This essay discusses Jorge Portilla’s phenomenological analysis of values and freedom in his essay, “The Phenomenology of Relajo.” Portilla argues that genuine freedom requires seriousness and sincerity; it requires wholehearted participation in cultural
Gallegos, Francisco
core  

Potential Competitive Effects of Vertical Mergers: A How-To Guide for Practitioners [PDF]

open access: yes, 2014
The purpose of this short article is to aid practitioners in analyzing the competitive effects of vertical and complementary product mergers. It is also intended to assist the agencies if and when they undertake revision of the 1984 U.S.
Culley, Daniel P., Salop, Steven C.
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Addressing disruptive medical staff behavior: a 3-year experience [PDF]

open access: yesEinstein (São Paulo)
Objective: To describe the 3-year long experience of addressing disruptive events by medical staff in a private hospital. Methods: The cross-sectional study that was conducted between 2020 and 2022, involved collection, analysis, and management of ...
Fernando Gatti de Menezes   +8 more
doaj   +1 more source

Managing EBD In and Out of the Classroom [PDF]

open access: yes, 2012
This metasynthesis of the literature focuses on managing students with emotional/behavioral disorders (EBD) inside and outside of the classroom. Students with EBD require large amounts of time and attention, often unplanned and in response to disruptive
Fielding, Estelita D.
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Parent-child interaction therapy for preschool children with disruptive behaviour problems in the Netherlands [PDF]

open access: yes, 2012
Background\ud Persistent high levels of aggressive, oppositional and impulsive behaviours, in the early lives of children, are significant risk factors for adolescent and adult antisocial behaviour and criminal activity.
Abrahamse, M.E.   +5 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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