Results 111 to 120 of about 122,020 (295)
Switch phenomenon in bipolar disorders: What is it?
Telangana Journal of Psychiatry, 2016 The phenomenon of Affective switch process is not well understood. It is difficult to differentiate switch from natural course of emergence of Manic/Hypomanic episodes.
Anand Bhogaraju
doaj +1 more source
Program for Education and Enrichment of Relational Skills: Parental Outcomes with an ADHD Sample [PDF]
, 2016 The goal of the current study was to examine the effect of PEERS®, a 14-week parent-assisted friendship-building program for adolescents with ADHD, on parental functioning, quality of the parent-adolescent relationship, and family functioning ...
Gonring, Kelsey
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Youth Gang Involvement and Long-Term Offending: An Examination into the Role of Psychopathic Traits
YouthMost policies to combat gang criminal behavior are rooted in deterrence and punitive strategies. This is fueled by moral panic, a get tough on crime rhetoric, and a lack of understanding for the psychological factors that may influence this behavior ...
Justin J. Joseph
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Too Many Teens: Preventing Unnecessary Out-Of-Home Placements [PDF]
, 2015 The child welfare system was created to care for abused and neglected children. But too often, teenagers are landing in the system because they simply aren't getting along with their parents.
Anne Holton, Roque Gerald, Tamara Horne
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Early Pathways Therapy for Young Children in Poverty: A Randomized Controlled Trial [PDF]
, 2015 Early Pathways is a home-based, parent and child therapy program for the treatment of disruptive behaviors among young children living in poverty. In this study, 199 clinically referred children were randomly assigned to an immediate treatment (IT) or ...
Fox, Robert A. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source