Results 101 to 110 of about 122,020 (295)

‘From Badness to Sickness’ and Back Again: The Use of Medication in the U.S. School and Foster Care Systems [PDF]

, 2018
This article explores the over- and under-prescription of psychotropic medication to youth of color both in public schools and the foster care system. Under the umbrella of the schools-to-prison pipeline, there is a wide array of literature addressing ...
Nemetz, Sarah J.
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Inattention, hyperactivity, oppositional-defiant symptoms and school failure Desatenção, hiperatividade, sintomas de oposição e desafio e fracasso escolar

Arquivos de Neuro-Psiquiatria, 2008
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is associated with school failure. Inattention has been mainly implicated for this association.
Maria Antonia Serra-Pinheiro, Paulo Mattos, Maria Angélica Regalla, Isabella de Souza, Cristiane Paixão   +4 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Behavioural disorders in children and adolescents: A conceptual review about the therapeutic alliance with family and school [PDF]

, 2017
Aim: In disruptive behavioral disorders, given the wide range of symptomatic manifestations and the complexity of the sociofamiliar contexts in which they develop, it is now proven that more visible and more stable results can be achieved over time ...
Barbanera F., Gallai B., Lavano F., Lavano S. M., Maltese A., Marotta R., Romano P., Salerno M., Tripi G., Valentini V.   +9 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Social, emotional and behavioural difficulties in young people : the challenge for policy makers [PDF]

, 2010
This paper considers some of the policy issues associated with social, emotional and behavioural difficulties (SEBD) in young people. After briefly defining SEBD the paper goes on to consider some of the ways in which SEBD impinges on different areas ...
Cooper, Paul
core   +1 more source

The behavioral parenting interventions (BPT) for support and mandatory integrative therapy for children and adolescents affected by disruptive behavioural disorders: A brief review [PDF]

, 2017
The behavioral parenting interventions (BPT), commonly abbreviated as parent training, is a program conducted by an expert with the specific purpose of improving or modifying parental practices in order to promote the child's well-being, increasing ...
Barbanera F., Di Folco A., Gallai B., Lavano F., Lavano S. M., Maltese A., Marotta R., Romano P., Salerno M., Tripi G., Valentini V.   +10 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source