Results 81 to 90 of about 122,020 (295)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Role of Executive Functions in the Development of Empathy and Its Association with Externalizing Behaviors in Children with Neurodevelopmental Disorders and Other Psychiatric Comorbidities

Brain Sciences, 2020
Executive functions have been previously shown to correlate with empathic attitudes and prosocial behaviors. People with higher levels of executive functions, as a whole, may better regulate their emotions and reduce perceived distress during the ...
Chiara Cristofani, Gianluca Sesso, Paola Cristofani, Pamela Fantozzi, Emanuela Inguaggiato, Pietro Muratori, Antonio Narzisi, Chiara Pfanner, Simone Pisano, Lisa Polidori, Laura Ruglioni, Elena Valente, Gabriele Masi, Annarita Milone   +13 more
doaj   +1 more source

Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study [PDF]

, 2013
Aim To examine the relationship between a childhood diagnosis of attention deficit hyperactivity disorder (ADHD) with or without oppositional defiant disorder (ODD)/conduct disorder (CD) and the development of later alcohol/drug use disorder ...
Buitelaar, JK, Faraone, SV, Franke, B, Groenman, AP, Oades, RD, Oosterlaan, J, Roeyers, Herbert, Rommelse, N, Sergeant, JA   +8 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children

Biological Psychiatry Global Open Science
Background: It is unclear how transdiagnostic symptoms including attention, disruptive behavior, and internalizing problems are linked to in-scanner motion in children across structural and functional magnetic resonance imaging (fMRI).
Kavari Hercules, Zhiyuan Liu, Eleni Christofilea, Jia Wei, Gladys Venegas, Olivia Ciocca, Alice Dyer, Goeun Lee, Sasha Santini-Bishop, Heather Shappell, Dylan G. Gee, Denis G. Sukhodolsky, Karim Ibrahim   +12 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effectiveness of parent management training in reducing oppositional and defiant behaviors in a clinical sample of Egyptian children

Middle East Current Psychiatry
Background Parenting plays a significant role in shaping a child’s behavior. Parent Management Training (PMT) is a well-established treatment for children with disruptive behavior disorders.
Mohammad A. Seleem, Reham A. Amer, Yasmeen A. Hasanen, Jess P. Shatkin   +3 more
doaj   +1 more source

Lifetime psychopathology among the offspring of Bipolar I parents

Clinics, 2011
BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series
Marcelo C. Zappitelli, Isabel A. Bordin, John P. Hatch, Sheila C. Caetano, Giovana Zunta-Soares, Rene L. Olvera, Jair C. Soares   +6 more
doaj   +1 more source

Incremental Clinical Utility of ADHD Assessment Measures With Latino Families [PDF]

, 2017
Objective: This study examined the incremental clinical utility of parent and teacher reports of ADHD symptomatology and functional impairment in Latino youth, as well as parent and teacher agreement with the final clinical judgment on a diagnostic ...
Castro, Al, Gerdes, Alyson C., Grace, Margaret, Kapke, Theresa Lauer   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source