Results 31 to 40 of about 429 (228)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Colourful Disruptions: Mapping the Multifactorial Landscape of International Biopolitics

Horyzonty Polityki
RESEARCH OBJECTIVE: The research aims to explore the evolution and multifactorial determinants of international biopolitics, emphasizing how global governance shapes biological life across borders. THE RESEARCH PROBLEMS AND METHODS: The study investigates international biopolitics as governance increasingly transitions from national to supranational ...
Wojciech Zysk, Marcin Gryczka
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adaptive colour polymorphism of Acrida ungarica H. (Orthoptera: Acrididae) in a spatially heterogeneous environment

, 2011
Intra-specific colour polymorphism provides a cryptic camouflage from predators in heterogeneous habitats. The orthoptera species, Acrida ungarica (Herbst, 1786) possess two well-distinguished colour morphs: brown and green and displays several ...
Julia Bilat, Brazzola, G., Perrin, N., Wassef, J., Fournier, B., Yannic, G., Gregory Brazzola, Pellissier, L., Nicolas Perrin, Colliard, C., Bilat, J., Pierrick Buri, Hausser, J., Glenn Yannic, Buri, P., Jérôme Wassef, Bertrand Fournier, Jacques Hausser, Caroline Colliard, Loïc Pellissier   +19 more
core   +1 more source

Changes in women's facial skin color over the ovulatory cycle are not detectable by the human visual system [PDF]

, 2015
RPB is supported by an Anniversary Research Fellowship at Northumbria University. MS and JT were supported by a David Philips Research Fellowship awarded to MS by the Biological Sciences Research Council (BBSRC) (BB/G022887/1).
Quigley, R., Saxton, Tamsin, Stevens, M., Robert P. Burriss (764579), Payne, J., Anthony J C Fulford, Robert P Burriss, Jenny Payne (764582), Lovell, P., Rowland, H., Martin Stevens, Burriss, Robert, P. George Lovell (764580), Rowland, Hannah M., Burriss, R., Lovell, P George, Jenny Payne, Fulford, Anthony JC, Saxton, Tamsin K, Martin Stevens (456599), Payne, Jenny, Jolyon Troscianko (456596), Troscianko, Jolyon, Jolyon Troscianko, Fulford, Anthony, Lovell, P. George, Burriss, Robert P, Hannah M. Rowland (764584), Stevens, Martin, Quigley, Rachael, Troscianko, J., Rowland, Hannah M, Rachael Quigley (764581), Fulford, Anthony J. C., Saxton, Tamsin K., Rachael Quigley, Rowland, Hannah, Tamsin K. Saxton (764583), Anthony J. C. Fulford (241917), Fulford, A., P George Lovell, Tamsin K Saxton, Lovell, P. George; id_orcid, Saxton, T., Burriss, Robert P., Hannah M Rowland   +45 more
core   +1 more source