Results 51 to 60 of about 429 (228)
The Role of Edge Enhancement in Animal Colouration
, 2021 Many animals exhibit contrasting shapes across their surface which are thought to help conceal them from potential predators. It has been suggested that these patterns, known as disruptive markings, function by creating false edges that break up the ...
JM Henderson (21999626)
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Distinctive yellow bands on a sit-and-wait predator: prey attractant or camouflage?
, 2006 Many animals have conspicuous body colour that may serve physiological, camouflage or communicative functions. This study investigated the influence of bright coloration in orb-web spiders on the response of predator and prey using Argiope keyserlingi ...
Law, E. A. J. +3 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Illustrations from Cott (1940) of the principles of differential blending and disruptive contrast.
, 2014 Note that the form-disrupting effect of high contrast between colour patches within an animal is more effective when these different parts of the animal match different parts of the background (right-hand versus middle pictures). Drawings were reproduced
Innes C. Cuthill (256664) +1 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Sexual dimorphism of vertical bar patterning in the South European toothcarp Aphanius fasciatus
, 2013 Sexual dimorphism of vertical bar patterning along the ontogenetic gradient was investigated in the South European toothcarp Aphanius fasciatus through the analysis of field samples collected from four different Venice Lagoon sites.
Zucchetta M. +7 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source