Results 41 to 50 of about 20,915 (250)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Medicine Forum, 2010 Introduction “Disruptive innovation” (DI) has recently been heralded as a tool to mitigate out of control health care spending in the UnitedStates,1,2,3 however few doctors are familiar with the concept. Overall, there is a tendency in medical culture to regard changes to established treatment and management models with some reticence, increasing the ...
Dalziel, MBBS, Peregrine, Shah, MD, Tina
openaire +4 more sources
Business Model as an Inducer of Disruptive Innovations: The Case of Gol Airlines
International Journal of Innovation, 2015 This study was undertaken to investigate the premises that the success of disruptive innovation is related to the business model adopted by organizations.
Sirlei de Almeida Pereira +3 more
doaj +1 more source
Characterization of Innovation to Fight Child Mortality: A Systematic Scoping Review
International Journal of Public Health, 2022 Objectives: This study aims to summarize how child mortality—a Sustainable Development Goal stated by the United Nations—has been explicitly addressed in the context of innovations.Methods: A scoping review following the PRISMA-ScR Statement was ...
Bruno Filipe Coelho Da Costa +5 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Frontiers in Energy Research, 2021 This study explores consumers’ motivations to switch to new products in the context of disruptive innovation and investigates the role of comparative economic value and green trust.
Chunpei Lin, Xiumei Lai, Chuanpeng Yu
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
UK higher education institutions’ technology-enhanced learning strategies from the perspective of disruptive innovation [PDF]
Research in Learning Technology, 2018 The publication of institutional strategies for learning, teaching and assessment in UK higher education is practically ubiquitous. Strategies for technology-enhanced learning are also widespread.
Michael Flavin, Valentina Quintero
doaj +1 more source