Results 51 to 60 of about 20,915 (250)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Venture capital participation, mitigation of financial constraints, and disruptive innovation in enterprises: A comparative study based on ownership heterogeneity

International Review of Economics & Finance
In the context of intensifying global technological competition and accelerating industrial transformation, disruptive innovation has become a crucial driving force for promoting high-quality economic development.
Jiaer Fei, Zhenlong Miao, Meng Li, Wen Liu   +3 more
doaj   +1 more source

Disruptive Innovation and the Idea of Technology

Novation, 2019
From its obscure origins in management theory, disruptive innovation has become one of the concepts used to describe how networked digital technologies and platforms transform industries and institutions.
Darryl Cressman
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

The duality of connectivity: how the connectivity of collaborative networks shapes disruptive innovation

Information Research: An International Electronic Journal
Introduction. This study first reveals the nonlinear impact mechanism of algebraic connectivity in scientific collaboration networks on disruptive innovation, offering a novel perspective for understanding the boundary effects of knowledge flow and the ...
Yingqun Li, Chuhui Zhang, Zhiwei Hu, Lei Pei   +3 more
doaj   +1 more source

The Risk and Reward Management in Innovation Portfolios: A Markovian Approach

Croatian Operational Research Review, 2018
Today, innovation is perceived as a source of competitive advantage for firms, playing a vital role in both the survival and growth of firms. A general look at the existing literature on innovation points toward a lack of studies that explore the risk ...
Sergio J. Chión, Vincent Charles
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Disruptive Intelligence - How to gather Information to deal with disruptive innovations

Journal of Intelligence Studies in Business, 2015
Disruptive innovations are innovations that have the capacity to transform a whole business into one with products that are more accessible and affordable (cf. Christensen et al. 2009). As Christensen et al.
Dirk Vriens, Klaus Solberg Søilen
doaj   +1 more source

Future Competition Law In Indonesia: Analysis Of The Phenomenon Of Disruptive Innovation

Syariah: Jurnal Hukum dan Pemikiran, 2021
Abstrak: Tujuan dari penelitian ini adalah untuk menganalisa status hukum dari ada nya disruptive innovation terhadap penerapan hukum persaingan usaha dan untuk menentukan arah kebijakan hukum persaingan usaha di Indonesia pada masa yang akan datang ...
Izzy Al Kautsar
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source