Results 61 to 70 of about 16,418 (252)

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Somatic PDGFRB activating variants in fusiform cerebral aneurysms [PDF]

, 2019
The role of somatic genetic variants in the pathogenesis of intracranial-aneurysm formation is unknown. We identified a 23-year-old man with progressive, right-sided intracranial aneurysms, ipsilateral to an impressive cutaneous phenotype.
Alcantara, Diana, Busald, Tina, Byers, Peter, Dobyns, William B, Dorschner, Michael O, Ferreira, Manuel, Gonzalez-Cuyar, Luis F, Hale, Christopher J, Karasozen, Yigit, Kim, Louis J, Murray, Mitzi, O'Driscoll, Mark, Osbun, Joshua W, Parada, Carolina Angelica, Tatman, Philip   +14 more
core   +1 more source

Study of Risk Factors and Image Findings of Isolated Abdominal Incidentally Detected Aortic Dissection

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 429-435, March/April 2025.
We detect the risk factors and image characteristics of incidentally detected IAAD. Independent risk factors of IAAD included fatty liver and smoking. In the ultrasound findings of IAAD, an intimal flap was frequently observed. In the CT scan, displacement of intimal calcifications was frequently observed. For suspected IAAD, the abdominal aorta should
Hiromasa Tsubouchi, Hidenori Onishi, Koji Maeno, Masaya Nakagaichi, Ikue Tsukushi, Youichi Kitano, Yoshitaka Makino, Hiroyuki Hayashi, Hidekazu Terasawa, Hiroko Kabuto, Toshihiro Misawa, Taku Sanada, Azusa Hisada, Kazuo Notsumata, Kazuhiro Okafuji, Osamu Yamamura   +15 more
wiley   +1 more source

Endovascular Versus Open Repair For Chronic Type B Dissection Treatment: A meta-analysis. [PDF]

, 2019
BACKGROUND: The respective place of endovascular versus open surgery in thoracic dissecting aneurysm treatment remains debatable. This comprehensive review seeks to analyse the outcomes of endovascular repair (ER) compared to open surgery (OS) in chronic
Boufi, M, Boyer, L, Grima, MJ, Holt, PJ, Loftus, IM, Loundou, AD, Patterson, BO   +6 more
core   +3 more sources

The “5L” framework of diagnostic reasoning: A stepwise scaffold to support clinician educators

Journal of Hospital Medicine, EarlyView.
Abstract Diagnostic reasoning (DR) is a core clinical skill, yet its teaching remains variable. We introduce the “5L” framework as a bedside teaching scaffold that gives educators and learners a shared, stepwise set of prompts for DR during individual encounters. By asking, “What's Lethal? What's Likely? What's Logical? What's Lurking?
Olivia Brumfield, Amal Mohamed, Shuhan He, Cory Rohlfsen   +3 more
wiley   +1 more source

Dissecting Aneurysms of Bilateral Anterior Cerebral Artery Complicated by Subarachnoid Hemorrhage after Cerebral Infarction: A Case Report

Clinical Medicine Insights: Case Reports, 2008
Introduction Intracranial dissecting aneurysms have been increased due to recent advancements in diagnostic imaging. However there have been little article with subarachnoid hemorrhage and cerebral infarction occurring almost at the same time.
Akihiro Kurosu, Shizuo Hatashita, Hideo Ueno   +2 more
doaj   +1 more source

Dissecting Aneurysms Of Posterior Cerebral Artery: Clinical Presentation, Angiographic Findings, Treatment and Outcome.

Frontiers in Neurology, 2011
:Background: The dissecting posterior cerebral artery (PCA) aneurysms are very rare. These aneurysms pose significant treatment challenge and need careful evaluation to formulate an optimal treatment plan in case of ruptured or un-ruptured presentations.
Muhammad A Taqi, Marc A. Lazzaro, Dhruvil J Pandya, Aamir eBadruddin, Osama O Zaidat   +4 more
doaj   +1 more source

Emergent hybrid surgical approaches for non-dissecting ruptured Kommerell's aneurysm: a case report series

Journal of Cardiothoracic Surgery, 2023
Background Kommerell’s aneurysm is a saccular or fusiform dilatation found in 3–8% of Kommerell’s diverticulum cases. A non-dissecting rupture rate of 6% has been reported. If ruptured, emergent surgical correction is usually granted.
Alejandro Velandia-Sánchez, Sebastián Gómez-Galán, Sebastian Gallo-Bernal, Camilo A. Polania-Sandoval, Ivonne G. Pineda-Rodríguez, Paula Florez-Amaya, Lina M. Sanabria-Arévalo, Julián Senosiain-González, Juan G. Barrera-Carvajal, Juan P. Umana, Jaime Camacho-Mackenzie   +10 more
doaj   +1 more source

Association of Cystic Medial Necrosis of the Aorta and Undiagnosed Thyroiditis [Scripta Medica] [PDF]

, 1977
We have recently seen two patients with cystic medial necrosis of the aorta. The first patient died of a dissecting aneurysm of the thoracic aorta. At autopsy, classical Hashimoto’s thyroiditis was discovered.
Hain, John R., Wise, William S.
core   +1 more source

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

, 2020
Arterial tortuosity syndrome (ATS) is a recessively inherited connective tissue disorder, mainly characterized by tortuosity and aneurysm formation of the major arteries.
Barnhoorn, Sander, Beyens, Aude, Boel, Annekatrien, Burger, Joyce, Callewaert, Bert, Casteleyn, Christophe, Coucke, Paul, Descamps, Benedicte, Essers, Jeroen, Reinhardt, Dieter, Renard, Marjolijn, van der Pluijm, Ingrid, Vanhomwegen, Marine, Vanhove, Christian, Willaert, Andy   +14 more
core   +1 more source