Results 81 to 90 of about 11,068 (262)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Comparison of Aneurysmal and Non-Aneurysmal Spontaneous Cervical Artery Dissections in a Large Multicenter Cohort

Clinical and Translational Neuroscience
Dissecting aneurysms in patients with spontaneous cervical artery dissections have, so far, been reported as “benign”, but more specific information is scarce. We aimed to elucidate (1) vascular risk factors, (2) local and ischemic symptoms, and (3) long-
Valentin K. Steinsiepe, Hakan Sarikaya, Pasquale R. Mordasini, Susanne Wegener, Corinne Inauen, Philipp Baumgartner, Simon Jung, Kateryna Antonenko, Urs Fischer, Jan Gralla, Roza M. Umarova, Barbara Goeggel Simonetti, Constance J. H. C. M. van Laarhoven, Gert J. de Borst, Hugues Chabriat, Mirjam R. Heldner, Marcel Arnold   +16 more
doaj   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Assessment of transesophageal doppler echography in dissecting aortic aneurysm

, 1989
To assess the clinical value of transesophageal Doppler echography in the diagnosis of dissecting aortic aneurysm, both transesophageal and conventional echograms were performed in 22 cases of dissecting aortic aneurysm.
Kawai, Chuichi, Nishimura, Kazunobu, Ban, Toshihiko, Osakada, Genta, Tamaki, Shunichi, Yamazato, Arid, Hashimoto, Satoshi, Kumada, Toshiaki, Tokunaga, Shingo, Kubo, Shigeru   +9 more
core   +1 more source

Deconstructive endovascular technique for dissecting posterior cerebral artery aneurysms: a single-center case series study

The Egyptian Journal of Radiology and Nuclear Medicine
Background This study aimed to evaluate the safety and efficacy of the endovascular deconstructive artery technique in the treatment of dissecting posterior cerebral artery (PCA) aneurysms (P1 and P2 segments).
Farouk Hassan, Ashraf Abdel Latif Osman, Ahmed S. Issa   +2 more
doaj   +1 more source

Chronic Type A Aortic Dissection: Rare Presentation of Incidental Pericardial Effusion

Case Reports in Cardiology, 2019
Aortic dissection is the most devastating sequelae of aortopathy other than aortic rupture. However, aortic dissection can be asymptomatic in the acute phase with delayed symptomatic presentation or incidental diagnosis upon chest imaging.
Ashraf Abugroun, Ahmed Subahi, Safwan Gaznabi, Hussein Daoud   +3 more
doaj   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Transformative Advances in Vascular Surgery: Five Decades of Innovation in the Management of Aortic, Carotid, and Peripheral Arterial Disease

World Journal of Surgery, EarlyView.
Ghaleb A. Darwazeh, William Q. Duong, Ramola M. Panchal, Ahmed M. Abou‐Zamzam   +3 more
wiley   +1 more source

First‐time red blood cell transfusions in the emergency department: A deficiency in micronutrient testing

Transfusion Medicine, EarlyView.
Abstract Objectives To evaluate laboratory investigations for micronutrient deficiencies as the cause of anaemia prior to first‐time red blood cell transfusions in the medical emergency department (ED) of a large academic hospital. Background The ED is often the first point of contact for acutely ill anaemic patients, yet patient blood management ...
Andrea Coetzee, Karryn Brown, Jessica Opie, Jody Rusch, Annemarie Kropman, Vernon Louw   +5 more
wiley   +1 more source