Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Deltoid muscle: a proposed classification system on human foetuses
Folia MorphologicaBACKGROUND: The deltoid muscle originates from the spine of the scapula, the lateral border of the acromion, and the lateral third of the clavicle. It inserts on the deltoid tuberosity.
Krzysztof Koptas +4 more
doaj +1 more source
Intravascular ultrasound imaging in acute aortic dissection
, 1994 Objectives. This study was performed to determine the potential of intravascular ultrasound in the detection and delineation of aortic dissection.Background.
Pandian, Natesa G. +5 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
A three-headed plantaris muscle fused with Kaplan fibres: potential clinical significance
Folia MorphologicaThe plantaris is a short, small muscle that usually originates at the popliteal surface of the femur and has a long, thin tendon that typically inserts into the calcaneal tuberosity.
Krystian Maślanka +4 more
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Spontaneous renal artery dissection associated with sexual intercourse: a case report
, 2018 Mohammed Elhassan, Shaikh Husnain, Raza Mian Department of Internal Medicine, Division of Hospital Medicine, University of California San Francisco (UCSF) Fresno Medical Education Program, Fresno, CA, USA Abstract: Spontaneous renal artery ...
Mian R, Husnain S, Elhassan M
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Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Hypoglossal Nerve Neuropathies—Analysis of Causes and Anatomical Background
BiomedicinesThe hypoglossal nerve is the last, and often neglected, cranial nerve. It is mainly responsible for motor innervation of the tongue and therefore the process of chewing and articulation.
Andrzej Węgiel +3 more
doaj +1 more source
Isolated spontaneous dissection of the celiac trunk in a patient with bicuspid aortic valve
, 2010 Abdel-Rauf Zeina1, Alicia Nachtigal1, Anton Troitsa2, Gil Admon2, Nina Avshovich31Department of Radiology, 2Department of Surgery A, 3Department of Internal Medicine C, Hillel Yaffe Medical Center, Hadera, Israel.
Anton Troitsa +3 more
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