Results 81 to 90 of about 1,215,713 (372)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

A very rare case report: accessory head of the sartorius muscle

Folia Morphologica
The sartorius muscle belongs to the anterior compartment of the thigh. Morphological variations of this muscle are very rare, few cases being described in the literature.
Nicol Zielinska, Richard Shane Tubbs, Adrian Balcerzak, Łukasz Olewnik   +3 more
doaj   +1 more source

Aortic dissection reconsidered: type, entry site, malperfusion classification adding clarity and enabling outcome prediction.

Interactive Cardiovascular and Thoracic Surgery, 2019
OBJECTIVES Aortic dissection is complex. Imaging and treatment modalities are evolving, demanding a more differentiated but pragmatic dissection classification.
H. Sievers, B. Rylski, M. Czerny, A. Baier, M. Kreibich, M. Siepe, F. Beyersdorf   +6 more
semanticscholar   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Two variant muscles in the gluteal region

Folia Morphologica
The short lateral rotators of the thigh found in the gluteal region can have morphological variations. During anatomical dissection of a right lower limb, two variant structures were found in this region.
Nicol Zielinska, Richard Shane Tubbs, Piotr Łabętowicz, Łukasz Olewnik   +3 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Accessory slip of fibularis tertius to extensor digitorum longus — an unreported variant

Folia Morphologica
The fibularis tertius (FT) is one of three muscles which constitute the anterior compartment of the leg. The anatomical variants of this muscle usually pertain to its origins, number of final tendons or points, and shapes of insertions. In the particular
Andrzej Węgiel, Nicol Zielinska, Krystian Maślanka, Bartosz Gonera, Konrad Kurtys, Łukasz Olewnik   +5 more
doaj   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Dissecting Tendermint

, 2019
In this paper we analyze Tendermint proposed in [7], one of the most popular blockchains based on PBFT Consensus. The current paper dissects Tendermint under various system communication models and Byzantine adversaries. Our methodology consists in identifying the algorithmic principles of Tendermint necessary for a specific combination of ...
Amoussou-Guenou, Yackolley, del Pozzo, Antonella, Potop-Butucaru, Maria, Tucci-Piergiovanni, Sara   +3 more
openaire   +3 more sources

Acute aortic dissection: pathogenesis, risk factors and diagnosis.

Swiss medical weekly, 2017
Acute aortic dissection is a rare but life-threatening condition with a lethality rate of 1 to 2% per hour after onset of symptoms in untreated patients.
J. Gawinecka, F. Schönrath, A. von Eckardstein   +2 more
semanticscholar   +1 more source